Mouse anti-Human MSTN Monoclonal Antibody | anti-MSTN antibody

Anti-MSTN Mouse mAb

Cat. Num. AAA476528

• Gene Names: MSTN; GDF8; MSLHP
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Synonyms: MSTN; Monoclonal Antibody; Anti-MSTN Mouse mAb; GDF8; MSLHP; anti-MSTN antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 6E4E6
• Form/Format: Purified antibody in PBS with 0.05% sodium azide.
• Sequence Length: 376

• Applicable Applications for anti-MSTN antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Purified recombinant fragment of human MSTN (AA:24-266) expressed in E Coli.

Western Blot (WB)

(Western blot analysis using MSTN mAb against human MSTN (AA:24-266) recombinant protein. (Expected MW is 28.9 kDa))

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using MSTN mouse mAb with DAB staining.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded liver cancer tissues using MSTN mouse mAb with DAB staining.)

Related Product Information for anti-MSTN antibody

Entrez Summary: The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.

NCBI and Uniprot Product Information

• NCBI GI #: 1018192768
• NCBI GeneID: 2660
• Molecular Weight: 42.8
• NCBI Official Full Name: MSTN
• NCBI Official Synonym Full Names: myostatin
• NCBI Official Symbol: MSTN
• NCBI Official Synonym Symbols: GDF8; MSLHP
• NCBI Protein Information: growth/differentiation factor 8
• UniProt Protein Name: Growth/differentiation factor 8
• Protein Family: Growth/differentiation factor
• UniProt Gene Name: MSTN
• UniProt Synonym Gene Names: GDF8; GDF-8

NCBI Description

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016]

Uniprot Description

MSTN: Acts specifically as a negative regulator of skeletal muscle growth. Defects in MSTN are the cause of muscle hypertrophy (MSLHP). MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q32.2

Cellular Component: extracellular space

Molecular Function: cytokine activity; identical protein binding; protein binding; receptor binding; transforming growth factor beta receptor binding

Biological Process: cell development; muscle development; muscle maintenance; negative regulation of myoblast differentiation; negative regulation of protein kinase B signaling cascade; negative regulation of skeletal muscle growth; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade

Disease: Muscle Hypertrophy