Receptor-type tyrosine-protein phosphatase eta (Ptprj) Recombinant Protein | Ptprj recombinant protein

Recombinant Mouse Receptor-type tyrosine-protein phosphatase eta (Ptprj) , partial

Cat. Num. AAA1461666

• Gene Names: Ptprj; BET; Byp; Scc1; CD148; DEP-1; Ptpb2; RPTPJ; Scc-1; AI450271; PTPbeta2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Receptor-type tyrosine-protein phosphatase eta (Ptprj); Recombinant Mouse Receptor-type tyrosine-protein phosphatase eta (Ptprj); partial; Ptprj recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,238

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Ptprj recombinant protein

This protein is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 208609939
• NCBI GeneID: 19271
• NCBI Accession #: NP_033008.3
• NCBI GenBank Nucleotide #: NM_008982.5
• UniProt Accession #: Q64455; Q3UH64; Q3UHL5; Q541R5; Q8CIW9; Q8K3Q2
• Molecular Weight: 136,769 Da
• NCBI Official Full Name: receptor-type tyrosine-protein phosphatase eta isoform 1
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, receptor type, J
• NCBI Official Symbol: Ptprj
• NCBI Official Synonym Symbols: BET; Byp; Scc1; CD148; DEP-1; Ptpb2; RPTPJ; Scc-1; AI450271; PTPbeta2
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase eta
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase eta
• Protein Family: Receptor-type tyrosine-protein phosphatase
• UniProt Gene Name: Ptprj
• UniProt Synonym Gene Names: Byp; Scc1; Protein-tyrosine phosphatase eta; R-PTP-eta; R-PTP-J

Uniprot Description

Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. May be involved in the mechanism of contact inhibition of cell growth. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.