PTMA recombinant protein

PTMA Protein, Human, Recombinant (GST Tag)

Cat. Num. AAA8120811

• Gene Names: PTMA; TMSA
• Purity: >90% as determined by SDS-PAGE
• Synonyms: PTMA; PTMA Protein; Human; Recombinant (GST Tag); Human PTMA Protein (GST Tag); TMSA Protein; prothymosin; alpha; PTMA recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.5. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Ser2-Asp111

• Species: Human
• Predicted N Terminal: Met
• Tag: N-GST
• Protein Construction: A DNA sequence encoding the human PTMA (P06454-1)(Ser 2-Asp 111) was fused with the GST tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for PTMA recombinant protein

Background: PTMA (prothymosin, alpha, N-GST chimera) is a small, 12.4kDa protein. It is a 109-111 amino acid long polypeptide as the precursor of thymosin a1. Thymosins are named becaues they were originally isolated from the thymus. But now in many other tissues, thymosins also can be detected. Thymosins have diverse biological activities, and two in particular, thymosins a1 and _4, have potentially important uses in medicine, some of which have already progressed from the laboratory to the clinic. In general, PTMA is associated with cellular proliferation and carcinogenesis (Eschenfeldt et al., 1986), cellular and viral transcription (Cotter et al., 2000), protection against apoptosis and chromatin remodelling (Karetsou et al., 1998). PTMA may have a dual role both intracellulary and extracellulary. In relation to diseases, thymosins have been categorized as biological response modifiers. Thymosin a1 is derived from PTMA. For animals that lack thymus glands, thymosin a1 is responsible for the activity of that preparation in restoring immune function.

References

Manrow RE, et al. (1992) The human prothymosin alpha gene family contains several processed pseudogenes lacking deleterious lesions. Genomics. 13(2):319-31.Wara DW, et al. (1975) Thymosin activity in patients with cellular immunodeficiency. N Engl J Med. 292(2):70-4.Garaci E, et al. (2007) Thymosin alpha 1: from bench to bedside. Ann N Y Acad Sci. 1112:225-34.Goldstein AL, et al. (2009) From lab to bedside: emerging clinical applications of thymosin alpha 1. Expert Opin Biol Ther. 9(5):593-608.

NCBI and Uniprot Product Information

• NCBI GI #: 135834
• NCBI GeneID: 5757
• UniProt Accession #: P06454; Q15249; Q15592
• Molecular Weight: 111
• NCBI Official Full Name: Prothymosin alpha
• NCBI Official Synonym Full Names: prothymosin, alpha
• NCBI Official Symbol: PTMA
• NCBI Official Synonym Symbols: TMSA
• NCBI Protein Information: prothymosin alpha; gene sequence 28; prothymosin alpha protein
• UniProt Protein Name: Prothymosin alpha
• Protein Family: Prothymosin
• UniProt Gene Name: PTMA
• UniProt Synonym Gene Names: TMSA
• UniProt Entry Name: PTMA_HUMAN

Uniprot Description

PTMA: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. Belongs to the pro/parathymosin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Cell cycle regulation

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: transcription, DNA-dependent