Chicken Focal adhesion kinase 1 ELISA Kit | PTK2 elisa kit
Chicken Focal adhesion kinase 1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
FAK: a tyrosine kinase of the FAK family required for cell migration and contact-dependent survival signaling. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Downstream of integrins and Src, upstream of Ras/MAPK. Localizes to focal adhesions that form between cells growing in the presence of extracellular matrix constituents. Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with Shb. Required for full Ras transformation of fibroblasts. Increased expression in breast and other cancers, related to chromosome 8q amplification. Overexpression and activation associated with increased migration, invasion and progression of ovarian cancer, and with progression in hepatocellular carcinoma, thyroid cancer, and acute myelogenous leukemia. siRNA increases chemosensitivity of pancreatic adenocarcinoma xenografts. Inhibitor: ISI15421 (antisense). Four splice-variant isoforms have been observed.
Protein type: EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Kinase, protein; TK group; Fak family
Cellular Component: cell; cytoplasm; extrinsic to internal side of plasma membrane; focal adhesion; microtubule organizing center; nucleus; perinuclear region of cytoplasm; sarcolemma
Molecular Function: ATP binding; calcium-dependent cysteine-type endopeptidase activity; identical protein binding; non-membrane spanning protein tyrosine kinase activity; protease binding; protein binding; protein-tyrosine kinase activity; receptor binding; signal transducer activity
Biological Process: actin filament organization; angiogenesis; angiogenesis involved in wound healing; cell adhesion; cell differentiation; cytoskeleton organization and biogenesis; epidermal growth factor receptor signaling pathway; innate immune response; negative regulation of apoptosis; negative regulation of protein amino acid autophosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation; positive regulation of focal adhesion formation; positive regulation of protein binding; protein amino acid autophosphorylation; proteolysis; pyramidal neuron migration; regulation of cell adhesion; regulation of cell proliferation; response to pH; signal complex assembly
Research Articles on PTK2
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Product Notes
The Chicken PTK2 ptk2 (Catalog #AAA2881625) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2881625 ELISA Kit recognizes Chicken PTK2. It is sometimes possible for the material contained within the vial of "Focal adhesion kinase 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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