Immunoprecipitation (IP)
(IP: 3T3 cell lysate incubated with F0019-55 (7ug), then probed with F0019-56.)
Mouse FAK Monoclonal Antibody | anti-FAK antibody
FAK (Focal Adhesion Associated Protein Tyrosine Kinase, BC3) (MaxLight 405)
Immunoprecipitation (IP)
(IP: 3T3 cell lysate incubated with F0019-55 (7ug), then probed with F0019-56.)
Immunoprecipitation (IP)
(IP: 3T3 cell lysate incubated with F0019-55 (7ug), then probed with F0019-56.)
NCBI and Uniprot Product Information
Uniprot Description
FAK: a tyrosine kinase of the FAK family required for cell migration and contact-dependent survival signaling. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Downstream of integrins and Src, upstream of Ras/MAPK. Localizes to focal adhesions that form between cells growing in the presence of extracellular matrix constituents. Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with Shb. Required for full Ras transformation of fibroblasts. Increased expression in breast and other cancers, related to chromosome 8q amplification. Overexpression and activation associated with increased migration, invasion and progression of ovarian cancer, and with progression in hepatocellular carcinoma, thyroid cancer, and acute myelogenous leukemia. siRNA increases chemosensitivity of pancreatic adenocarcinoma xenografts. Inhibitor: ISI15421 (antisense). Four splice-variant isoforms have been observed.
Protein type: Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; TK group; Fak family
Cellular Component: extrinsic to internal side of plasma membrane; focal adhesion; perinuclear region of cytoplasm; microtubule organizing center; nucleus
Molecular Function: identical protein binding; protein binding; signal transducer activity; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding
Biological Process: epidermal growth factor receptor signaling pathway; regulation of cell adhesion; cell migration; peptidyl-tyrosine phosphorylation; signal complex assembly; innate immune response; cytoskeleton organization and biogenesis; angiogenesis; cell differentiation; regulation of cell proliferation; negative regulation of apoptosis
Research Articles on FAK
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Product Notes
The FAK ptk2 (Catalog #AAA6244703) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The FAK (Focal Adhesion Associated Protein Tyrosine Kinase, BC3) (MaxLight 405) reacts with Avian, Chicken, Human, Rodent and may cross-react with other species as described in the data sheet. AAA Biotech's FAK can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the FAK ptk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FAK, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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