Prostaglandin F2-alpha receptor (PTGFR) Recombinant Protein | PTGFR recombinant protein

Recombinant Human Prostaglandin F2-alpha receptor (PTGFR), partial

• Gene Names: PTGFR; FP
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Prostaglandin F2-alpha receptor (PTGFR); Recombinant Human Prostaglandin F2-alpha receptor (PTGFR); partial; PTGFR recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 274

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 4506261
• NCBI GeneID: 5737
• NCBI Accession #: NP_000950.1
• NCBI GenBank Nucleotide #: NM_000959.3
• UniProt Accession #: P43088; Q2KHP3; Q6RYQ6; Q9P1X4; A8K9Y0
• Molecular Weight: 30,766 Da
• NCBI Official Full Name: prostaglandin F2-alpha receptor isoform a
• NCBI Official Synonym Full Names: prostaglandin F receptor
• NCBI Official Symbol: PTGFR
• NCBI Official Synonym Symbols: FP
• NCBI Protein Information: prostaglandin F2-alpha receptor
• UniProt Protein Name: Prostaglandin F2-alpha receptor
• Protein Family: Prostaglandin F2-alpha receptor
• UniProt Gene Name: PTGFR
• UniProt Synonym Gene Names: PGF receptor; PGF2-alpha receptor

NCBI Description

The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.