Prostagladin E synthase 3 Recombinant Protein | PTGES3 recombinant protein

Prostagladin E synthase 3, 1-160aa, Human, E Coli

Cat. Num. AAA203477

• Gene Names: PTGES3; P23; TEBP; cPGES
• Applications: SDS-Page
• Purity: > 95% by SDS-PAGE
• Synonyms: Prostagladin E synthase 3; 1-160aa; Human; E Coli; PTGES3; cPGES; P23; TEBP; HSP90 co-chaperone; Sid 3177; Co chaperone p23; Hsp90 co chaperone; Cytosolic prostaglandin E2 synthase; Progesterone receptor complex; Progesterone receptor complex p23; Prostaglandin E synthase 3; PTGES 3; Telomerase binding protein p23; unactive progesterone receptor 23 kD; ; PTGES3 recombinant protein

• Host: E Coli
• Purity/Purification: > 95% by SDS-PAGE
• Form/Format: Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 10% glycerol
• Concentration: 0.5 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MQPASAKWYD RRDYVFIEFC VEDSKDVNVN FEKSKLTFSC LGGSDNFKHL NEIDLFHCID PNDSKHKRTD RSILCCLRKG ESGQSWPRLT KERAKLNWLS VDFNNWKDWE DDSDEDMSNF DRFSEMMNNM GGDEDVDLPE VDGADDDSQD SDDEKMPDLE
• Sequence Length: 160

• Applicable Applications for PTGES3 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for PTGES3 recombinant protein

Prostaglandin E synthase 3 (PTGES3), also known as P23 or TEBP (Telomerase binding protein p23), is a ubiquitously expressed protein that functions as a cochaperone and plays an important role in signal transduction. This protein is a molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Recombinant PTGES3 protein was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for PTGES3 recombinant protein

Heat Shock Proteins

References

Hawkins GA., et al. (2009) J Allergy Clin Immunol. 123 (6):1376-83.e7; Nuttinck F., et al. (2008) Reproduction. 135 (5):593-603.;

NCBI and Uniprot Product Information

• NCBI GI #: 23308579
• NCBI GeneID: 10728
• NCBI Accession #: NP_006592
• NCBI GenBank Nucleotide #: NM_006601.6
• UniProt Accession #: Q15185; Q8WU70; A8K7D0; B4DHP2; B4DP11; B4DP21
• Molecular Weight: 18.6 kDa (160aa), confirmed by MALDI-TOF.
• NCBI Official Full Name: prostaglandin E synthase 3 isoform a
• NCBI Official Synonym Full Names: prostaglandin E synthase 3
• NCBI Official Symbol: PTGES3
• NCBI Official Synonym Symbols: P23; TEBP; cPGES
• NCBI Protein Information: prostaglandin E synthase 3
• UniProt Protein Name: Prostaglandin E synthase 3
• Protein Family: Prostaglandin E synthase
• UniProt Gene Name: PTGES3
• UniProt Synonym Gene Names: P23; TEBP; cPGES

NCBI Description

This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016]

Uniprot Description

Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).