Prostagladin E synthase 3 Recombinant Protein | PTGES3 recombinant protein
Prostagladin E synthase 3, 1-160aa, Human, E Coli
Gene Names
PTGES3; P23; TEBP; cPGES
Applications
SDS-Page
Purity
> 95% by SDS-PAGE
Synonyms
Prostagladin E synthase 3; 1-160aa; Human; E Coli; PTGES3; cPGES; P23; TEBP; HSP90 co-chaperone; Sid 3177; Co chaperone p23; Hsp90 co chaperone; Cytosolic prostaglandin E2 synthase; Progesterone receptor complex; Progesterone receptor complex p23; Prostaglandin E synthase 3; PTGES 3; Telomerase binding protein p23; unactive progesterone receptor 23 kD; ; PTGES3 recombinant protein
Host
E Coli
Purity/Purification
> 95% by SDS-PAGE
Form/Format
Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 10% glycerol
Concentration
0.5 mg/ml (determined by Bradford assay) (varies by lot)
Sequence
MQPASAKWYD RRDYVFIEFC VEDSKDVNVN FEKSKLTFSC LGGSDNFKHL NEIDLFHCID PNDSKHKRTD RSILCCLRKG ESGQSWPRLT KERAKLNWLS VDFNNWKDWE DDSDEDMSNF DRFSEMMNNM GGDEDVDLPE VDGADDDSQD SDDEKMPDLE
Sequence Length
160
Applicable Applications for PTGES3 recombinant protein
SDS-PAGE
Antigen Species
Human
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
SDS-Page
Related Product Information for PTGES3 recombinant protein
Prostaglandin E synthase 3 (PTGES3), also known as P23 or TEBP (Telomerase binding protein p23), is a ubiquitously expressed protein that functions as a cochaperone and plays an important role in signal transduction. This protein is a molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Recombinant PTGES3 protein was expressed in E Coli and purified by using conventional chromatography techniques.
Product Categories/Family for PTGES3 recombinant protein
References
Hawkins GA., et al. (2009) J Allergy Clin Immunol. 123 (6):1376-83.e7; Nuttinck F., et al. (2008) Reproduction. 135 (5):593-603.;
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
18.6 kDa (160aa), confirmed by MALDI-TOF.
NCBI Official Full Name
prostaglandin E synthase 3 isoform a
NCBI Official Synonym Full Names
prostaglandin E synthase 3
NCBI Official Symbol
PTGES3
NCBI Official Synonym Symbols
P23; TEBP; cPGES
NCBI Protein Information
prostaglandin E synthase 3
UniProt Protein Name
Prostaglandin E synthase 3
Protein Family
UniProt Gene Name
PTGES3
UniProt Synonym Gene Names
P23; TEBP; cPGES
NCBI Description
This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016]
Uniprot Description
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).
