Chemical Structure
(Chemical structure of Radicicol (SIH-117), a Hsp90 inhibitor. CAS #: 12772-57-5. Molecular Formula: C18H17CIO6. Molecular Weight: 364.8 g/mol.)
Radicicol Small Molecule
Radicicol
Purity
97% by TLC
Synonyms
Radicicol; Hsp90 inhibitor; Radicicol small molecule
Host
Produced by fermentation
Purity/Purification
97% by TLC
Form/Format
White to Yellow Solid
Solubility
Soluble in DMSO
CAS Number
12772-57-5
Molecular Formula
C18H17CIO6
SMILES
COc1ccc2c(=O)c(coc2c1OC)c3cc(c(cc3I)OC)OC
InChI
1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1
InChI Key
WYZWZEOGROVVHK-GTMNPGAYSA-N
PubChem CID
6323491
PubMed ID
20220516
Preparation and Storage
Store at -20 degree C.
Chemical Structure
(Chemical structure of Radicicol (SIH-117), a Hsp90 inhibitor. CAS #: 12772-57-5. Molecular Formula: C18H17CIO6. Molecular Weight: 364.8 g/mol.)
Chemical Structure
(Chemical structure of Radicicol (SIH-117), a Hsp90 inhibitor. CAS #: 12772-57-5. Molecular Formula: C18H17CIO6. Molecular Weight: 364.8 g/mol.)
Related Product Information for Radicicol small molecule
Radicicol inhibits src (IC50=0.27uM) and src-like kinases(1), leading to hypophosphorylation of retinoblastoma tumor suppressor protein(2). It causes morphological reversion of ras-transformed cells(3) and leads to selective depletion of Raf kinase(4). It also displays anti-angiogenic activity(5), and binds to and inhibits Hsp 90 molecular chaperone(6). It binds more strongly to Hsp90 than to GRP94. It also binds to yeast HSP90, E Coli HtpG and TRAP-1.
Product Categories/Family for Radicicol small molecule
References
1. Kwon H.J., et al. (1992) Cancer Res. 52: 6929. 2. Yen A., et al. (1994) Exp.Cell Res. 214: 163. 3. Kwon H.J., et al. (1995) J.Biochem.(Tokyo) 118: 221. 4. Soga S., et al. (1998) J.Biol.Chem. 273: 822. 5. Oikawa T., et al. (1993) Eur.J.Pharmacol. 241: 221. 6. Roe S.M. et al. (1999) J.Med.Chem. 42: 260.
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Product Notes
The Radicicol (Catalog #AAA807924) is a Small Molecule produced from Produced by fermentation and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Radicicol, Small Molecule" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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