Activity
(Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.)
CK1 alpha 1L Recombinant Protein | CK1alpha1L recombinant protein
CK1 alpha 1L, Active
Gene Names
CSNK1A1L; CK1
Applications
Western Blot
Synonyms
CK1 alpha 1L; Active; CSNK1A1L; CK1A1L; CK1alpha1L; CK1; MGC33182; RP11-532O21.2; CK1alpha1L recombinant protein
Host
Sf9 insect cells
Form/Format
Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Applicable Applications for CK1alpha1L recombinant protein
Kinase Assay, Western Blot (WB)
Tag
GST
Species
Human
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Activity
(Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.)
Activity
(Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.)
SDS-Page
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
SDS-Page
(Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.)
Related Product Information for CK1alpha1L recombinant protein
Recombinant full-length human CK1alpha1L was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is BC028723.
CK1alpha1L or casein kinase 1, alpha 1 like is a novel member of the CKI gene family which highlights a critical role for p53 in invasiveness control (1). CK1-alpha dynamically associates with the CBM complex on T cell receptor engagement to participate in cytokine production and lymphocyte proliferation which has a contrasting role by subsequently promoting the phosphorylation and inactivation of CARMA1 and it governs antigen-receptor-induced NF-kappa-B activation and human lymphoma cell survival (2).
CK1alpha1L or casein kinase 1, alpha 1 like is a novel member of the CKI gene family which highlights a critical role for p53 in invasiveness control (1). CK1-alpha dynamically associates with the CBM complex on T cell receptor engagement to participate in cytokine production and lymphocyte proliferation which has a contrasting role by subsequently promoting the phosphorylation and inactivation of CARMA1 and it governs antigen-receptor-induced NF-kappa-B activation and human lymphoma cell survival (2).
Product Categories/Family for CK1alpha1L recombinant protein
References
1. Elyada, E.et.al: CKI-alpha ablation highlights a critical role for p53 in invasiveness control. Nature 470: 409-413, 2011.
2. Bidere, N.et.al: Casein kinase 1-alpha governs antigen-receptor-induced NF-kappa-B activation and human lymphoma cell survival. Nature 458: 92-96, 2009.
2. Bidere, N.et.al: Casein kinase 1-alpha governs antigen-receptor-induced NF-kappa-B activation and human lymphoma cell survival. Nature 458: 92-96, 2009.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
39,086 Da
NCBI Official Full Name
Homo sapiens casein kinase 1, alpha 1-like, mRNA
NCBI Official Synonym Full Names
casein kinase 1 alpha 1 like
NCBI Official Symbol
CSNK1A1L
NCBI Official Synonym Symbols
CK1
NCBI Protein Information
casein kinase I isoform alpha-like
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Product Notes
The CK1alpha1L (Catalog #AAA516756) is a Recombinant Protein produced from Sf9 insect cells and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CK1 alpha 1L can be used in a range of immunoassay formats including, but not limited to, Kinase Assay, Western Blot (WB). Researchers should empirically determine the suitability of the CK1alpha1L for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CK1 alpha 1L, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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