RelA-associated inhibitor (PPP1R13L) Recombinant Protein | PPP1R13L recombinant protein

Recombinant Human RelA-associated inhibitor (PPP1R13L) , partial

• Gene Names: PPP1R13L; RAI; RAI4; IASPP; NKIP1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: RelA-associated inhibitor (PPP1R13L); Recombinant Human RelA-associated inhibitor (PPP1R13L); partial; PPP1R13L recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 828

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 215820635
• NCBI GeneID: 10848
• NCBI Accession #: NP_001135974.1
• NCBI GenBank Nucleotide #: NM_001142502.1
• UniProt Accession #: Q8WUF5; Q2PNZ9; Q5DU71; Q5I1X4; Q6P1R7; Q6PKF8; Q9Y290
• Molecular Weight: 89,091 Da
• NCBI Official Full Name: relA-associated inhibitor
• NCBI Official Synonym Full Names: protein phosphatase 1 regulatory subunit 13 like
• NCBI Official Symbol: PPP1R13L
• NCBI Official Synonym Symbols: RAI; RAI4; IASPP; NKIP1
• NCBI Protein Information: relA-associated inhibitor
• UniProt Protein Name: RelA-associated inhibitor
• Protein Family: RelA-associated inhibitor
• UniProt Gene Name: PPP1R13L
• UniProt Synonym Gene Names: IASPP; NKIP1; PPP1R13BL; RAI; Protein iASPP

NCBI Description

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

Uniprot Description

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.