Rabbit anti-Human PPP1R13L Polyclonal Antibody | anti-PPP1R13L antibody

PPP1R13L Antibody (N-Term)

Cat. Num. AAA9216491

• Gene Names: PPP1R13L; RAI; RAI4; IASPP; NKIP1
• Reactivity: Human
• Applications: Western Blot
• Synonyms: PPP1R13L; Polyclonal Antibody; PPP1R13L Antibody (N-Term); Purified Rabbit Polyclonal Antibody (Pab); RelA-associated inhibitor; Inhibitor of ASPP protein; Protein iASPP; NFkB-interacting protein 1; PPP1R13B-like protein; IASPP; NKIP1; PPP1R13BL; RAI; anti-PPP1R13L antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This PPP1R13L antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 134-166 amino acids from human PPP1R13L.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 828

• Applicable Applications for anti-PPP1R13L antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:2000
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(All lanes : Anti-PPP1R13L Antibody (N-Term) at 1:2000 dilutionLane 1: MCF-7 whole cell lysatesLane 2: Hela whole cell lysatesLane 3: NCI-H1299 whole cell lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilutionPredicted band size : 89 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-PPP1R13L antibody

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.

Product Categories/Family for anti-PPP1R13L antibody

Crown Antibodies; Cancer; Cell Biology

References

Slee E.A.,et al.Oncogene 23:9007-9016(2004). Herron B.J.,et al.Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases. Yang J.-P.,et al.J. Biol. Chem. 274:15662-15670(1999). Takada N.,et al.J. Virol. 76:8019-8030(2002). Bergamaschi D.,et al.Nat. Genet. 33:162-167(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 215820635
• NCBI GeneID: 10848
• NCBI Accession #: NP_001135974.1
• NCBI GenBank Nucleotide #: NM_001142502.1
• UniProt Accession #: Q8WUF5; Q2PNZ9; Q5DU71; Q5I1X4; Q6P1R7; Q6PKF8; Q9Y290
• Molecular Weight: 89091
• NCBI Official Full Name: relA-associated inhibitor
• NCBI Official Synonym Full Names: protein phosphatase 1 regulatory subunit 13 like
• NCBI Official Symbol: PPP1R13L
• NCBI Official Synonym Symbols: RAI; RAI4; IASPP; NKIP1
• NCBI Protein Information: relA-associated inhibitor
• UniProt Protein Name: RelA-associated inhibitor
• Protein Family: RelA-associated inhibitor
• UniProt Gene Name: PPP1R13L
• UniProt Synonym Gene Names: IASPP; NKIP1; PPP1R13BL; RAI; Protein iASPP
• UniProt Entry Name: IASPP_HUMAN

NCBI Description

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

Uniprot Description

PPP1R13L: an oncoprotein that interacts with and inhibits NF-kappaB, Sp1 and p53. Plays a central role in regulation of apoptosis and transcription. May inhibit p53 by preventing its association with ASPP1 or ASPP2, thereby suppressing the subsequent activation of apoptosis. Required for neuronal survival after axonal injury. Two alternatively spliced isoforms have been described. Isoform 1 is preferrentially found in the cytoplasm; isoform 2 is nuclear.

Protein type: Phosphatase, regulatory subunit; Apoptosis; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: intercellular bridge; cytoplasm; cell junction; nucleus

Molecular Function: identical protein binding; protein binding; transcription factor binding; transcription corepressor activity

Biological Process: transcription, DNA-dependent; apoptosis; multicellular organism growth; negative regulation of transcription from RNA polymerase II promoter; multicellular organismal homeostasis; positive regulation of cell differentiation; embryonic camera-type eye development; post-embryonic development; cardiac muscle contraction; hair cycle