Rabbit anti-Human PPP1R13L Polyclonal Antibody | anti-PPP1R13L antibody

PPP1R13L (RelA-associated Inhibitor, Inhibitor of ASPP Protein, Protein iASPP, NFkB-interacting Protein 1, PPP1R13B-like Protein, IASPP, NKIP1, PPP1R13BL, RAI)

Cat. Num. AAA649374

• Gene Names: PPP1R13L; RAI; RAI4; IASPP; NKIP1
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: PPP1R13L; Polyclonal Antibody; PPP1R13L (RelA-associated Inhibitor; Inhibitor of ASPP Protein; Protein iASPP; NFkB-interacting Protein 1; PPP1R13B-like Protein; IASPP; NKIP1; PPP1R13BL; RAI); Anti -PPP1R13L (RelA-associated Inhibitor; anti-PPP1R13L antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PPP1R13L.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MDSEAFQSARDFLDMNFQSLAMKHMDLKQMELDTAAAKVDELTKQLESLWSDSPAPPGPQAGPPSRPPRYSSSSIPEPFGSRGSPRKAATDGADTPFGRSESAPTLHPYSPLSPKGRPSSPRTPLYLQPDAYGSLDRATSPRPRAFDGAGSSLGRAPSPRPGPGPLRQQGPPTPFDFLGRAGSPRGSPLAEGPQAFFSERGPSPRPPATAYDAPASAFGSSLLGSGGSAFAPPLRAQDDLTLRRRPPKAWNESDLDVAYEKKPSQTASYERLDVFARPASPSLQLLPWRESSLDGLGGTGKDNLTSATLPRNYKVSPLASDRRSDAGSYRRSLGSAGPSGTLPRSWQPVSRIPMPPSSPQPRGAPRQRPIPLSMIFKLQNAFWEHGASRAMLPGSPLFTRAPPPKLQPQPQPQPQPQSQPQPQLPPQPQTQPQTPTPAPQHPQQTWPPVNEGPPKPPTELEPEPEIEGLLTPVLEAGDVDEGPVARPLSPTRLQPALPPEAQSVPELEEVARVLAEIPRPLKRRGSMEQAPAVALPPTHKKQYQQIISRLFHRHGGPGPGGPEPELSPITEGSEARAGPPAPAPPAPIPPPAPSQSSPPEQPQSMEMRSVLRKAGSPRKARRARLNPLVLLLDAALTGELEVVQQAVKEMNDPSQPNEEGITALHNAICGANYSIVDFLITAGANVNSPDSHGWTPLHCAASCNDTVICMALVQHGAAIFATTLSDGATAFEKCDPYREGYADCATYLADVEQSMGLMNSGAVYALWDYSAEFGDELSFREGESVTVLRRDGPEETDWWWAALHGQEGYVPRNYFGLFPRVKPQRSKV

• Applicable Applications for anti-PPP1R13L antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human PPP1R13L, aa1-828 (AAH64913.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of PPP1R13L expression in transfected 293T cell line by PPP1R13L polyclonal antibody. Lane 1: PPP1R13L transfected lysate (89.1kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-PPP1R13L antibody

Inhibitor of apoptosis stimulating protein of p53 (iASPP) plays a central role in regulation of apoptosis and transcription via its interaction with NFkB and p53 proteins. At present, the iASPP gene is thought to encode three isoforms; isoform 1 is predominantly located in the cytoplasm, whilst isoforms 2 and 3 are nuclear proteins. iASPP is highly expressed in the heart, placenta and prostate. iASPP has been shown to have oncogenic properties in human breast carcinomas.

Product Categories/Family for anti-PPP1R13L antibody

Antibodies; Abs to Enzymes; Phosphatase

NCBI and Uniprot Product Information

• NCBI GI #: 33876266
• NCBI GeneID: 10848
• UniProt Accession #: Q8WUF5; Q2PNZ9; Q5DU71; Q5I1X4; Q6P1R7; Q6PKF8; Q9Y290
• Molecular Weight: 89,091 Da
• NCBI Official Full Name: PPP1R13L protein, partial
• NCBI Official Synonym Full Names: protein phosphatase 1, regulatory subunit 13 like
• NCBI Official Symbol: PPP1R13L
• NCBI Official Synonym Symbols: RAI; RAI4; IASPP; NKIP1
• NCBI Protein Information: relA-associated inhibitor; protein iASPP; PPP1R13B-like protein; retinoic acid induced 4; inhibitor of ASPP protein; NFkB interacting protein 1; NFkB-interacting protein 1; inhibitor of apoptosis stimulating protein of p53; protein phosphatase 1, regulatory (inhibitor) subunit 13 like
• UniProt Protein Name: RelA-associated inhibitor
• Protein Family: RelA-associated inhibitor
• UniProt Gene Name: PPP1R13L
• UniProt Synonym Gene Names: IASPP; NKIP1; PPP1R13BL; RAI; Protein iASPP
• UniProt Entry Name: IASPP_HUMAN

NCBI Description

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

Uniprot Description

Function: Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. Ref.1 Ref.5 Ref.6 Ref.7

Subunit structure: Interacts with RELA NF-kappa-B subunit and with SP1 via its C-terminus part. Interacts with p53/TP53, TP63 and TP73. Ref.1 Ref.5 Ref.6 Ref.7 Ref.15

Subcellular location: Cytoplasm. Nucleus. Note: Predominantly cytoplasmic but also nuclear. Ref.1 Ref.5

Tissue specificity: Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. Ref.5

Domain: Isoform 1 N-terminal region is required for cytoplasmic localization.

Sequence similarities: Belongs to the ASPP family.Contains 2 ANK repeats.Contains 1 SH3 domain.

Sequence caution: The sequence AAD27004.1 differs from that shown. Reason: Frameshift at positions 439, 483, 562 and 591. The sequence AAD27005.1 differs from that shown. Reason: Frameshift at positions 483, 562 and 591. The sequence AAD27005.1 differs from that shown. Reason: Probable cloning artifact.