Cyclophilin B / PPIB / CYPB Recombinant Protein | CYPB recombinant protein

Recombinant Human Cyclophilin B / PPIB / CYPB Protein (His tag)

Cat. Num. AAA2545970

• Gene Names: PPIB; OI9; CYPB; SCYLP; CYP-S1; HEL-S-39
• Purity: > 96 % as determined by SDS-PAGE
• Synonyms: Cyclophilin B / PPIB / CYPB; Recombinant Human Cyclophilin B / PPIB / CYPB Protein (His tag); CYP-S1; CYPB; MGC14109; MGC2224; OI9; SCYLP; PPIB; CYPB recombinant protein

• Host: Human Cells
• Purity/Purification: > 96 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 216

• Application Notes: The recombinant human PPIB consists of 190 amino acids and migarates as an approximately 22 kDa band in SDS-PAGE under reducing conditions as predicted.
• Predicted N Terminal: Asp 34
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for CYPB recombinant protein

A DNA sequence encoding the mature form of human PPIB (NP_000933.1) (Asp 34-Ala 212) was fused with a signal peptide at the N-terminus and a polyhistidine tag at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 4758950
• NCBI GeneID: 5479
• NCBI Accession #: NP_000933.1
• NCBI GenBank Nucleotide #: NM_000942.4
• UniProt Accession #: P23284; Q6IBH5; Q9BVK5; A8K534
• Molecular Weight: 23,743 Da
• NCBI Official Full Name: peptidyl-prolyl cis-trans isomerase B
• NCBI Official Synonym Full Names: peptidylprolyl isomerase B
• NCBI Official Symbol: PPIB
• NCBI Official Synonym Symbols: OI9; CYPB; SCYLP; CYP-S1; HEL-S-39
• NCBI Protein Information: peptidyl-prolyl cis-trans isomerase B
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase B
• Protein Family: Bifunctional cytochrome P450/NADPH--P450 reductase
• UniProt Gene Name: PPIB
• UniProt Synonym Gene Names: CYPB; PPIase B; SCYLP

NCBI Description

The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]

Uniprot Description

PPIB: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9). OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients. Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.

Protein type: Chaperone; Cyclophilin; EC 5.2.1.8; Isomerase; RNA-binding; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q22.31

Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; focal adhesion; membrane; nucleus; perinuclear region of cytoplasm

Molecular Function: collagen binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; protein complex binding; unfolded protein binding

Biological Process: positive regulation of multicellular organism growth; protein peptidyl-prolyl isomerization; protein stabilization

Disease: Osteogenesis Imperfecta, Type Ix