Rabbit anti-Human PTPN18 Polyclonal Antibody | anti-PTPN18 antibody

PTPN18, CT (PTPN18, BDP1, Tyrosine-protein phosphatase non-receptor type 18, Brain-derived phosphatase)

Cat. Num. AAA649290

• Gene Names: PTPN18; BDP1; PTP-HSCF
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: PTPN18; Polyclonal Antibody; CT (PTPN18; BDP1; Tyrosine-protein phosphatase non-receptor type 18; Brain-derived phosphatase); Anti -PTPN18; anti-PTPN18 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-PTPN18 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: PTPN18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 429-459 amino acids from the C-terminal region of human PTPN18.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(PTPN18 Antibody (C-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the PTPN18 antibody detected the PTPN18 protein (arrow).)

Western Blot (WB)

(Western blot analysis of PTPN18 (arrow) using rabbit polyclonal PTPN18 Antibody (C-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PTPN18 gene.)

Related Product Information for anti-PTPN18 antibody

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Product Categories/Family for anti-PTPN18 antibody

Antibodies; Abs to Enzymes; Phosphatase

NCBI and Uniprot Product Information

• NCBI GI #: 31127083
• NCBI GeneID: 26469
• UniProt Accession #: Q99952; Q53P42; B4E1E6
• Molecular Weight: 50,482 Da
• NCBI Official Full Name: PTPN18 protein
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
• NCBI Official Symbol: PTPN18
• NCBI Official Synonym Symbols: BDP1; PTP-HSCF
• NCBI Protein Information: tyrosine-protein phosphatase non-receptor type 18; brain-derived phosphatase
• UniProt Protein Name: Tyrosine-protein phosphatase non-receptor type 18
• Protein Family: Tyrosine-protein phosphatase non-receptor
• UniProt Gene Name: PTPN18
• UniProt Synonym Gene Names: BDP1
• UniProt Entry Name: PTN18_HUMAN

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

Uniprot Description

Function: Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.

Catalytic activity: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subunit structure: Interacts with PSTPIP1

By similarity.

Subcellular location: Nucleus

By similarity. Cytoplasm

By similarity.

Tissue specificity: Expressed in brain, colon and several tumor-derived cell lines. Ref.1

Sequence similarities: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.Contains 1 tyrosine-protein phosphatase domain.