Cyclophilin B Recombinant Protein | PPIB recombinant protein

Cyclophilin B Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8120622

• Gene Names: PPIB; OI9; CYPB; SCYLP; CYP-S1; HEL-S-39
• Purity: >96% as determined by SDS-PAGE
• Synonyms: Cyclophilin B; Cyclophilin B Protein; Human; Recombinant (His Tag); Human Cyclophilin B/PPIB/CYPB Protein (His Tag); CYP-S1 Protein; CYPB Protein; HEL-S-39 Protein; OI9 Protein; SCYLP Protein; peptidylprolyl isomerase B (cyclophilin B); PPIB recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >96% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Asp34-Ala212

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Asp 34
• Tag: C-His
• Protein Construction: A DNA sequence encoding the mature form of human PPIB (NP_000933.1)(Asp 34-Ala 212) was fused with a signal peptide at the N-terminus and a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for PPIB recombinant protein

Background: PPIB is identified as a candidate gene for OI-IX. Osteogenesis imperfecta (OI) is an inherited disorder of connective tissue typically caused by defects in either COL1A1 or COL1A2. A number of other genes causative of this disorder have been found, including PPIB, which forms one subunit of the prolyl 3-hydroxylase enzyme complex. Patients with OI caused by PPIB mutation should have appropriate early and regular management of their hearing.

Product Categories/Family for PPIB recombinant protein

Phosphatases and Regulators

NCBI and Uniprot Product Information

• NCBI GI #: 4758950
• NCBI GeneID: 5479
• NCBI Accession #: NP_000933.1
• NCBI GenBank Nucleotide #: NM_000942.4
• UniProt Accession #: P23284; Q6IBH5; Q9BVK5; A8K534
• Molecular Weight: 23,743 Da
• NCBI Official Full Name: peptidyl-prolyl cis-trans isomerase B
• NCBI Official Synonym Full Names: peptidylprolyl isomerase B
• NCBI Official Symbol: PPIB
• NCBI Official Synonym Symbols: OI9; CYPB; SCYLP; CYP-S1; HEL-S-39
• NCBI Protein Information: peptidyl-prolyl cis-trans isomerase B
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase B
• Protein Family: Probable peptidyl-prolyl cis-trans isomerase
• UniProt Gene Name: PPIB
• UniProt Synonym Gene Names: CYPB; PPIase B; SCYLP
• UniProt Entry Name: PPIB_HUMAN

Uniprot Description

PPIB: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9). OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients. Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.

Protein type: Isomerase; EC 5.2.1.8; Chaperone; Cyclophilin; Secreted, signal peptide; RNA-binding; Secreted

Chromosomal Location of Human Ortholog: 15q21-q22

Cellular Component: smooth endoplasmic reticulum; focal adhesion; membrane; perinuclear region of cytoplasm; endoplasmic reticulum lumen; endoplasmic reticulum; melanosome; nucleus

Molecular Function: collagen binding; protein binding; peptidyl-prolyl cis-trans isomerase activity; unfolded protein binding; protein complex binding; peptide binding

Biological Process: extracellular matrix organization and biogenesis; protein peptidyl-prolyl isomerization; protein stabilization; positive regulation of multicellular organism growth

Disease: Osteogenesis Imperfecta, Type Ix