Protein Tyrosine Phosphatase F Interacting Protein 1 Recombinant Protein | PPFIA1 recombinant protein

Recombinant Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1)

Cat. Num. AAA2034498

• Gene Names: PPFIA1; LIP1; LIP.1; LIPRIN
• Reactivity: Human
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: >95%
• Synonyms: Protein Tyrosine Phosphatase F Interacting Protein 1; Recombinant Protein Tyrosine Phosphatase F Interacting Protein 1 (PPFIA1); LIP.1; LIP1; LIPRIN; Liprin-Alpha 1; LAR-interacting protein 1; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1; PPFIA1 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: >95%
• Sequence Length: 917

• Applicable Applications for PPFIA1 recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Fragment: Met1~Ala250
• Tag: Two N-terminal Tags, His-tag and T7-tag
• Expression System: Prokaryotic Expression
• Preparation and Storage: Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 119595171
• NCBI GeneID: 8500
• Molecular Weight: 31.8kDa
• NCBI Official Full Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1, isoform CRA_c
• NCBI Official Synonym Full Names: PTPRF interacting protein alpha 1
• NCBI Official Symbol: PPFIA1
• NCBI Official Synonym Symbols: LIP1; LIP.1; LIPRIN
• NCBI Protein Information: liprin-alpha-1
• UniProt Protein Name: Liprin-alpha-1
• Protein Family: Liprin
• UniProt Gene Name: PPFIA1
• UniProt Synonym Gene Names: LIP1; LIP-1; PTPRF-interacting protein alpha-1
• UniProt Entry Name: LIPA1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

liprin alpha 1: a ubiqutous member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Two alternatively spliced isoforms have been described.

Protein type: Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: cytoplasm; cytosol; focal adhesion; presynaptic active zone

Molecular Function: protein binding; signal transducer activity

Biological Process: cell-matrix adhesion; glutamate secretion; negative regulation of stress fiber formation; neurotransmitter secretion; signal transduction; synaptic transmission