Rabbit CNP Polyclonal Antibody | anti-CNP antibody

CNP antibody

Cat. Num. AAA9412487

• Gene Names: CNP; CNP1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: CNP; Polyclonal Antibody; CNP antibody; CNPase; CNP1; anti-CNP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total CNP antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 421

• Applicable Applications for anti-CNP antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500 - 1:2000
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human CNP.
• Target Name: CNP
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using CNP antibody.)

Related Product Information for anti-CNP antibody

CNPase (2', 3¡¯-cyclic nucleotide 3'-phosphodiesterase) catalyzes the in vitro hydrolysis of 2¡¯, 3¡¯-cyclic nucleotides to produce 2¡¯-nucleotides. The in vivo molecular function and native substrate of this nucleotide phosphodiesterase remains under investigation (1). High CNPase expression is seen in oligodendrocytes and Schwann cells as CNPase accounts for roughly 4% of the total myelin protein in the central nervous system (2). CNPase binds to tubulin heterodimers and plays a role in tubulin polymerization, and oligodendrocyte process outgrowth (3). Typical myelination is seen in CNPase knock-out mice, but they suffer severe neurodegeneration from axonal loss and oligodendrocytes display abnormal paranodal loop structure prior to axonal degeneration. Paranodal loops typically contact the axolemma in axon-glial signaling; neurodegeneration in CNPase knock-out mice is a secondary consequence of impaired cell-cell communication (4).

Product Categories/Family for anti-CNP antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 94721261
• NCBI GeneID: 1267
• NCBI Accession #: NP_149124.3
• NCBI GenBank Nucleotide #: NM_033133.4
• UniProt Accession #: P09543
• Molecular Weight: 45,099 Da
• NCBI Official Full Name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase
• NCBI Official Synonym Full Names: 2',3'-cyclic nucleotide 3' phosphodiesterase
• NCBI Official Symbol: CNP
• NCBI Official Synonym Symbols: CNP1
• NCBI Protein Information: 2',3'-cyclic-nucleotide 3'-phosphodiesterase
• UniProt Protein Name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase
• Protein Family: 2',3'-cyclic-nucleotide 3'-phosphodiesterase
• UniProt Gene Name: CNP
• UniProt Synonym Gene Names: CNP; CNPase
• UniProt Entry Name: CN37_HUMAN

Uniprot Description

CNP: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. Exists as monomers and homodimers. Belongs to the cyclic nucleotide phosphodiesterase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; EC 3.1.4.37; Phosphodiesterase

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: extracellular space; microtubule; microvillus; pseudopodium; nucleoplasm; mitochondrial outer membrane; membrane; perinuclear region of cytoplasm; cytoplasm; mitochondrial inner membrane; plasma membrane; melanosome; nucleus

Molecular Function: cyclic nucleotide binding; RNA binding; 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity

Biological Process: synaptic transmission; substantia nigra development; axonogenesis; adult locomotory behavior; response to toxin; forebrain development; oligodendrocyte differentiation; response to lipopolysaccharide; microtubule cytoskeleton organization and biogenesis; regulation of mitochondrial membrane permeability; cyclic nucleotide catabolic process; aging