Western Blot (WB)
CAB39 positive control
CAB39 Antibody Positive Control
Western Blot (WB)
Western Blot (WB)
Component of a complex tthat binds and activates STK11/LKB1.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a glycosylphosphatidylinositol (GPI)-specific phospholipase that primarily localizes to the Golgi apparatus. This ubiquitously expressed gene is predicted to encode a seven-transmembrane protein that removes unsaturated fatty acids from the sn-2 position of GPI. The remodeling of the constituent fatty acids on GPI is thought to be important for the proper association between GPI-anchored proteins and lipid rafts. The tethering of proteins to plasma membranes via posttranslational GPI-anchoring is thought to play a role in protein sorting and trafficking. Mutations in this gene cause the autosomal recessive neurologic disorder hyperphosphatasia with mental retardation syndrome 4 (HPMRS4). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]
Uniprot Description
CAB39: a adaptor protein that, together with STRAD-alpha, forms a regulatory complex capable of stimulating the activity of LKB1. Interacts with Mst4, which plays an essential role in brush border formation in intestinal epithelial cells.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: cytosol
Molecular Function: kinase binding; protein binding; protein kinase activator activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity
Biological Process: activation of protein kinase activity; cell cycle arrest; peptidyl-serine phosphorylation; protein heterooligomerization
Research Articles on CAB39
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Product Notes
The CAB39 cab39 (Catalog #AAA542588) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CAB39 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:500. Researchers should empirically determine the suitability of the CAB39 cab39 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CAB39, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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