Western Blot (WB)
(Western Blot analysis of 293T and LoVo cell, Human brain malignant glioma tissue using CAB39 Polyclonal Antibody at dilution of 1:450)
Rabbit CAB39 Polyclonal Antibody | anti-CAB39 antibody
CAB39 Polyclonal Antibody
Gene Names
CAB39; MO25; CGI-66
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Antigen affinity purification
Synonyms
CAB39; Polyclonal Antibody; CAB39 Polyclonal Antibody; MO25; CGI-66; anti-CAB39 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen affinity purification
Concentration
2.9mg/mL (varies by lot)
Sequence Length
341
Applicable Applications for anti-CAB39 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
WB: 1:500-1:2000
IHC: 1:50-1:200
IHC: 1:50-1:200
Immunogen
Synthetic peptide of human CAB39
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Western Blot (WB)
(Western Blot analysis of 293T and LoVo cell, Human brain malignant glioma tissue using CAB39 Polyclonal Antibody at dilution of 1:450)
Western Blot (WB)
(Western Blot analysis of 293T and LoVo cell, Human brain malignant glioma tissue using CAB39 Polyclonal Antibody at dilution of 1:450)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human cervical cancer using CAB39 Polyclonal Antibody at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human cervical cancer using CAB39 Polyclonal Antibody at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human gastric cancer using CAB39 Polyclonal Antibody at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human gastric cancer using CAB39 Polyclonal Antibody at dilution of 1:50)
Related Product Information for anti-CAB39 antibody
Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha). STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
39,869 Da
NCBI Official Full Name
calcium-binding protein 39
NCBI Official Synonym Full Names
calcium binding protein 39
NCBI Official Symbol
CAB39
NCBI Official Synonym Symbols
MO25; CGI-66
NCBI Protein Information
calcium-binding protein 39; MO25alpha
UniProt Protein Name
Calcium-binding protein 39
Protein Family
UniProt Gene Name
CAB39
UniProt Synonym Gene Names
MO25
UniProt Entry Name
CAB39_HUMAN
Uniprot Description
CAB39: a adaptor protein that, together with STRAD-alpha, forms a regulatory complex capable of stimulating the activity of LKB1. Interacts with Mst4, which plays an essential role in brush border formation in intestinal epithelial cells.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: cytosol
Molecular Function: protein serine/threonine kinase activity; protein serine/threonine kinase activator activity; protein binding; protein kinase activator activity; kinase binding
Biological Process: protein heterooligomerization; activation of protein kinase activity; insulin receptor signaling pathway; cell cycle arrest; positive regulation of peptidyl-serine phosphorylation; protein amino acid phosphorylation
Research Articles on CAB39
Similar Products
Product Notes
The CAB39 cab39 (Catalog #AAA2518480) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CAB39 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CAB39 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:2000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the CAB39 cab39 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CAB39, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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