Axl positive control
Axl Positive Control
Receptor tyrosine kinase that transduces signals from the ECM into cytoplasm by binding growth factor GAS6. Regulates survival, proliferation, migration and differentiation.
NCBI and Uniprot Product Information
Uniprot Description
AXL: a receptor tyrosine kinase that may function as a signal transducer between specific cell types of mesodermal origin. Interacts with SKP1. Overexpression in tissue culture causes oncogenic transformation. Overexpressed in several cancers including thyroid, ovarian, gastric, ER+ breast cancer and acute myeloid leukemia, where it is associated with poor prognosis. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Kinase, protein; Membrane protein, integral; Protein kinase, TK; EC 2.7.10.1; Oncoprotein; Protein kinase, tyrosine (receptor); TK group; Axl family
Cellular Component: cell surface; extracellular space; integral to membrane; membrane; plasma membrane
Molecular Function: ATP binding; kinase activity; myosin heavy chain binding; nucleotide binding; phosphatidylserine binding; phosphoinositide 3-kinase binding; protein heterodimerization activity; protein kinase activity; protein-tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: apoptotic cell clearance; blood vessel remodeling; cell differentiation; cellular response to extracellular stimulus; entry of virus into host cell; enzyme linked receptor protein signaling pathway; erythrocyte homeostasis; forebrain cell migration; immune system process; inflammatory response; innate immune response; natural killer cell differentiation; negative regulation of apoptosis; negative regulation of interferon-gamma production; negative regulation of lymphocyte activation; negative regulation of neuron apoptosis; negative regulation of tumor necrosis factor production; neuron migration; ovulation cycle; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; platelet activation; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of natural killer cell differentiation; positive regulation of pinocytosis; positive regulation of protein kinase B signaling cascade; protein amino acid phosphorylation; protein kinase B signaling cascade; secretion by cell; spermatogenesis; vagina development
Research Articles on Axl
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Product Notes
The Axl axl (Catalog #AAA542554) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Axl can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:500. Researchers should empirically determine the suitability of the Axl axl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Axl, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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