Tyrosine-protein kinase receptor UFO/AXL oncogene/UFO Recombinant Protein | UFO recombinant protein

Recombinant Mouse Tyrosine-protein kinase receptor UFO/AXL oncogene/UFO (C-6His)

Cat. Num. AAA2569339

• Gene Names: Axl; Ark; Ufo; Tyro7; AI323647
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: Tyrosine-protein kinase receptor UFO/AXL oncogene/UFO; Recombinant Mouse Tyrosine-protein kinase receptor UFO/AXL oncogene/UFO (C-6His); Tyrosine-protein kinase receptor UFO; AXL oncogene; UFO; UFO recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Ala26-Pro440

• Species: Mouse
• Tag: C-6His
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Mouse Tyrosine-protein kinase receptor UFO is produced by our Mammalian expression system and the target gene encoding Ala19-Pro443 is expressed with a 6His tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for UFO recombinant protein

Axl, also known as Ufo and Ark, is a widely expressed 140kDa glycoprotein in the TAM receptor tyrosine kinase family. Axl binds the vitamin K-dependent protein Gas6 which triggers tyrosine autophosphorylation of the Axl cytoplasmic domain. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is highly expressed in solid cancers and promotes in vivo tumorigenesis and tumor cell invasiveness. It also functions as a cellular entry receptor for Gas6-opsonized lentiviruses. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo.

NCBI and Uniprot Product Information

• NCBI GI #: 342187104
• NCBI GeneID: 26362
• UniProt Accession #: Q00993; Q80YQ3
• Molecular Weight: 98,191 Da
• NCBI Official Full Name: Tyrosine-protein kinase receptor UFO
• NCBI Official Synonym Full Names: AXL receptor tyrosine kinase
• NCBI Official Symbol: Axl
• NCBI Official Synonym Symbols: Ark; Ufo; Tyro7; AI323647
• NCBI Protein Information: tyrosine-protein kinase receptor UFO; ufo oncogene homolog; adhesion-related kinase
• UniProt Protein Name: Tyrosine-protein kinase receptor UFO
• Protein Family: Protein UNUSUAL FLORAL ORGANS
• UniProt Gene Name: Axl
• UniProt Synonym Gene Names: Ark; Ufo
• UniProt Entry Name: UFO_MOUSE

Uniprot Description

AXL: a receptor tyrosine kinase that may function as a signal transducer between specific cell types of mesodermal origin. Interacts with SKP1. Overexpression in tissue culture causes oncogenic transformation. Overexpressed in several cancers including thyroid, ovarian, gastric, ER+ breast cancer and acute myeloid leukemia, where it is associated with poor prognosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Oncoprotein; Kinase, protein; TK group; Axl family

Cellular Component: extracellular space; cell surface; membrane; cell; integral to membrane; plasma membrane; intracellular

Molecular Function: transferase activity; phosphatidylserine binding; protein heterodimerization activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; phosphoinositide 3-kinase binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; myosin heavy chain binding; protein kinase activity

Biological Process: peptidyl-tyrosine phosphorylation; neuron migration; protein amino acid phosphorylation; enzyme linked receptor protein signaling pathway; positive regulation of natural killer cell differentiation; erythrocyte homeostasis; ovulation cycle; natural killer cell differentiation; negative regulation of interferon-gamma production; protein kinase B signaling cascade; negative regulation of neuron apoptosis; inflammatory response; cell differentiation; secretion by cell; forebrain cell migration; negative regulation of lymphocyte activation; platelet activation; immune system process; vagina development; negative regulation of tumor necrosis factor production; phagocytosis; positive regulation of protein kinase B signaling cascade; cellular response to extracellular stimulus; innate immune response; spermatogenesis; blood vessel remodeling; positive regulation of cytokine and chemokine mediated signaling pathway; phosphorylation; apoptotic cell clearance; negative regulation of apoptosis