Paraoxonase 2 Recombinant Protein | PON2 recombinant protein
Paraoxonase 2, Recombinant, Human (PON2, Serum paraoxonase arylesterase 2, A-esterase 2, Aromatic esterase 2)
~95% (SDS-PAGE). Single band on Western Blot.
~95% (SDS-PAGE). Single band on Western Blot.
Recombinant Human Paraoxonase-2 is expressed in E. coli having a molecular weight of 43.5kD and fused to an amino terminal hexahistidine tag.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
PON2: Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. Belongs to the paraoxonase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.1.2; EC 3.1.1.81; Motility/polarity/chemotaxis; Hydrolase
Chromosomal Location of Human Ortholog: 7q21.3
Cellular Component: mitochondrion; lysosome; extracellular region; plasma membrane; nucleus
Molecular Function: identical protein binding; arylesterase activity; metal ion binding
Biological Process: response to oxidative stress; aromatic compound catabolic process
Research Articles on PON2
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Product Notes
The PON2 pon2 (Catalog #AAA636103) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. Suitable for use as a positive control in Western Blot, ELISA, Immunoprecipitation and other immunological experiments. Other applications not tested. Researchers should empirically determine the suitability of the PON2 pon2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MGRLVAVGLL GIALALLGER LLALRNRLKA SREVESVDLP HCHLIKGIEA GSEDID ILPNGLAFFS VGLKFPGLHS FAPDKPGGIL MMDLKEEKPR ARELRISRGF DLASFNP HGISTFIDND DTVYLFVVNH PEFKNTVEIF KFEEAENSLL HLKTVKHELL PSVNDIT AVGPAHFYAT NDHYFSDPFL KYLETYLNLH WANVVYYSPN EVKVVAEGFD SAN GINISPDDKY IYVADILAHE IHVLEKHTNM NLTQLKVLEL DTLVDNLSID PSSGDIW VGCHPNGQKL FVYDPNNPPS SEVLRIQNIL SEKPTVTTVY ANNGSVLQGS SVASVY DGKLLIGTLY HRALYCELZ. It is sometimes possible for the material contained within the vial of "Paraoxonase 2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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