Structure
Chiglitazar Biochemical
Chiglitazar
Purity
>98% (HPLC)
Synonyms
Chiglitazar; CS-038; CS038; Chiglitazar biochemical
Purity/Purification
>98% (HPLC)
Target
PPAR
Receptor
PPAR
Chemical Name
3-(4-(2-(9H-carbazol-9-yl)ethoxy)phenyl)-2-((2-(4-fluorobenzoyl)phenyl)amino)propanoic acid sodium salt
SMILES
C1=CC=C2C(=C1)C3=CC=CC=C3N2CCOC4=CC=C(C=C4)CC(C(=O)[O-])NC5=CC=CC=C5C(=O)C6=CC=C(C=C6)F.[Na+]
Molecular Formula
C36H28FN2NaO4
CAS Number
1959588-75-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Chiglitazar biochemical
Chiglitazar (CS-038, CS038) is a potent, dual PPARalpha/gamma dual agonist with EC50 of 1.2, 0.08, 1.7uM for PPARalpha, PPARgamma and PPARdelta, respectively; inhibited alanine gluconeogenesis, lowered the hepatic glycogen level in MSG obese rats. Like rosiglitazone, chiglitazar promoted the differentiation of adipocytes and decreased the maximal diameter of adipocytes; Chiglitazar reduced plasma triglyceride, total cholesterol (TCHO), nonesterified fatty acids (NEFA) and low density lipoprotein-cholesterol levels; lowered hepatic triglyceride and TCHO contents; decreased muscular NEFA level. Unlike rosiglitazone, chiglitazar showed significant increase of mRNA expression of PPARalpha, CPT1, BIFEZ, ACO and CYP4A10 in the liver of MSG obese rats. Diabetes Phase 3 Clinical
Product Categories/Family for Chiglitazar biochemical
References
1. Li PP, et al. Br J Pharmacol. 2006 Jul; 148 (5):610-8.
2. He BK, et al. PPAR Res. 2012; 2012:546548.
3. Pan DS, et al. PPAR Res. 2017; 2017:4313561.
2. He BK, et al. PPAR Res. 2012; 2012:546548.
3. Pan DS, et al. PPAR Res. 2017; 2017:4313561.
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Product Notes
The Chiglitazar (Catalog #AAA3603073) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Chiglitazar, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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