Rabbit anti-Human, Mouse ZRANB1 Polyclonal Antibody | anti-ZRANB1 antibody
ZRANB1 Antibody
Gene Names
ZRANB1; TRABID
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
ZRANB1; Polyclonal Antibody; ZRANB1 Antibody; DKFZp762P2216; hTrabid; Trabid; TRAF-binding protein domain; Ubiquitin thioesterase ZRANB1; Zinc finger Ran-binding domain-containing protein 1; ZRAN1_HUMAN; anti-ZRANB1 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
ZRANB1 Antibody detects endogenous levels of ZRANB1.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-ZRANB1 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human ZRANB1.
Conjugation
Unconjugated
Similarity
The OTU domain mediates the deubiquitinating activity. The RanBP2-type zinc fingers mediate the specific interaction with 'Lys-63'-linked ubiquitin. The second ankyrin repeat ANK 2 is termed AnkUBD, it interacts with ubiquitin hydrophobic patch and contributes to linkage specificity. The RanBP2-type zinc fingers, also called NZFs, may provide additional ubiquitin-binding sites when hydrolyzing long 'Lys-63'-linked chains. Belongs to the peptidase C64 family.
Subunit Structure
Interacts with APC and TRAF6.
Tissue Specificity
Widely expressed.
Function
Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.
Note
Enriched in punctate localization in the cytoplasm.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
80,967 Da
NCBI Official Full Name
ubiquitin thioesterase ZRANB1
NCBI Official Synonym Full Names
zinc finger RANBP2-type containing 1
NCBI Official Symbol
ZRANB1
NCBI Official Synonym Symbols
TRABID
NCBI Protein Information
ubiquitin thioesterase ZRANB1
UniProt Protein Name
Ubiquitin thioesterase ZRANB1
Protein Family
UniProt Gene Name
ZRANB1
UniProt Synonym Gene Names
TRABID; hTrabid
UniProt Entry Name
ZRAN1_HUMAN
Research Articles on ZRANB1
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Product Notes
The ZRANB1 zranb1 (Catalog #AAA9630217) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ZRANB1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ZRANB1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the ZRANB1 zranb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ZRANB1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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