Immunofluorescence (IF)
(Immunofluorescent analysis of Hela cells using MBS7052517 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Rabbit anti-Human ZNF207 Polyclonal Antibody | anti-ZNF207 antibody
ZNF207 Antibody
Gene Names
ZNF207; BuGZ; hBuGZ
Reactivity
Human
Applications
ELISA, Immunofluorescence
Purity
>95%, Protein G purified
Synonyms
ZNF207; Polyclonal Antibody; ZNF207 Antibody; BUB3-interacting and GLEBS motif-containing protein ZNF2072; Zinc finger protein 207; anti-ZNF207 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Sequence Length
463
Applicable Applications for anti-ZNF207 antibody
ELISA (EIA), Immunofluorescence (IF)
Application Notes
IF: 1:50-1:200
Immunogen
Recombinant Human BUB3-interacting and GLEBS motif-containing protein ZNF207 protein (206-463AA)
Conjugation
Non-conjugated
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Immunofluorescence (IF)
(Immunofluorescent analysis of Hela cells using MBS7052517 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Immunofluorescence (IF)
(Immunofluorescent analysis of Hela cells using MBS7052517 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Related Product Information for anti-ZNF207 antibody
Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
52,694 Da
NCBI Official Full Name
BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform b
NCBI Official Synonym Full Names
zinc finger protein 207
NCBI Official Symbol
ZNF207
NCBI Official Synonym Symbols
BuGZ; hBuGZ
NCBI Protein Information
BUB3-interacting and GLEBS motif-containing protein ZNF207
UniProt Protein Name
BUB3-interacting and GLEBS motif-containing protein ZNF207
Protein Family
UniProt Gene Name
ZNF207
UniProt Synonym Gene Names
hBuGZ
Uniprot Description
ZNF207: 3 isoforms of the human protein are produced by alternative splicing.
Protein type: C2H2-type zinc finger protein; Spliceosome; Transcription factor
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: kinetochore; nucleolus; nucleus
Molecular Function: microtubule binding; protein binding
Biological Process: attachment of spindle microtubules to kinetochore; microtubule bundle formation; microtubule polymerization; mitotic cell cycle spindle assembly checkpoint; mitotic sister chromatid segregation; protein stabilization; regulation of chromosome segregation
Research Articles on ZNF207
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Product Notes
The ZNF207 znf207 (Catalog #AAA7052517) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ZNF207 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ZNF207 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunofluorescence (IF). IF: 1:50-1:200. Researchers should empirically determine the suitability of the ZNF207 znf207 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ZNF207, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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