Rabbit ZIP2 Polyclonal Antibody | anti-SLC39A2 antibody

ZIP2 Antibody

Cat. Num. AAA151383

• Gene Names: SLC39A2; 6A1; ZIP2; ETI-1; ZIP-2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: ZIP2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: ZIP2; Polyclonal Antibody; ZIP2 Antibody; 6A1; ETI-1; ZIP-2; Zinc transporter ZIP2; solute carrier family 39 (zinc transporter); member 2; anti-SLC39A2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: ZIP2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 309

• Applicable Applications for anti-SLC39A2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: ZIP2 antibody can be used for detection of ZIP2 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: ZIP2 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human ZIP2.; The immunogen is located within amino acids 70-120 of ZIP2
• Buffer: ZIP2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Molecular Weight: Predicted: 34kDa; Observed: 32kDa
• Preparation and Storage: ZIP2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of ZIP2 in (A) mouse and (B) rat brain tissue lysate with ZIP2 antibody at 1 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of ZIP2 in human brain tissue with ZIP2 antibody at 2.5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of ZIP2 in human brain tissue with ZIP2 antibody at 20 μg/mL.)

Related Product Information for anti-SLC39A2 antibody

ZIP2 Antibody: The zinc transporter ZIP2, also known as SLC39A2, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. Similar to knock-outs of ZIP1 and ZIP3, ZIP2-null mice have no phenotypic differences compared to wild-type mice. Only when ZIP1, ZIP2, and ZIP3 genes are all eliminated and these mutant mice are fed a zinc-deficient diet do abnormalities such as reduced embryonic-membrane bound alkaline phosphatase activity and abnormal development occur, indicating that the ZIP1-3 proteins play an important, noncompensatory role when zinc is deficient. More recent studies have shown that ZIP2 and ZIP3 are down regulated in human prostate adenocarcinomatous glands, and may be important in the retention of zinc in the cellular compartment.

NCBI and Uniprot Product Information

• NCBI GI #: 156415986
• NCBI GeneID: 29986
• NCBI Accession #: NP_055394
• NCBI GenBank Nucleotide #: NM_014579.3
• UniProt Accession #: Q9NP94; Q4QQJ1; Q4V9S4; Q96JT6; Q9UD20; B2RC76; G3V5X2
• NCBI Official Full Name: zinc transporter ZIP2 isoform a
• NCBI Official Synonym Full Names: solute carrier family 39 (zinc transporter), member 2
• NCBI Official Symbol: SLC39A2
• NCBI Official Synonym Symbols: 6A1; ZIP2; ETI-1; ZIP-2
• NCBI Protein Information: zinc transporter ZIP2; zinc uptake transporter 2; Zrt- and Irt-like protein 2; solute carrier family 39 member 2
• UniProt Protein Name: Zinc transporter ZIP2
• Protein Family: Zinc transporter
• UniProt Gene Name: SLC39A2
• UniProt Synonym Gene Names: ZIP2; ZIP-2; hZIP2
• UniProt Entry Name: S39A2_HUMAN

NCBI Description

This gene encodes a member of the ZIP family of metal ion transporters. The encoded protein functions as a zinc transporter. Mutations in this gene may be associated with susceptibility to carotid artery disease. Multiple transcript variants have been described. [provided by RefSeq, Mar 2010]

Uniprot Description

SLC39A2: Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis. Belongs to the ZIP transporter (TC 2.A.5) family.

Protein type: Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: integral to plasma membrane; cytoplasmic membrane-bound vesicle; plasma membrane

Molecular Function: zinc ion transmembrane transporter activity

Biological Process: zinc ion transport; transmembrane transport