Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human breast cancer using MBS1495644 at dilution 1:100)
Rabbit anti-Human Zinc finger protein 346 Polyclonal Antibody | anti-ZNF346 antibody
Rabbit anti-human Zinc finger protein 346 polyclonal Antibody(ZNF346)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human breast cancer using MBS1495644 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human breast cancer using MBS1495644 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human tonsil using MBS1495644 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human tonsil using MBS1495644 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human placenta using MBS1495644 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human placenta using MBS1495644 at dilution 1:100)
Immunoprecipitation (IP)
(Immunoprecipitating ZNF346 in HepG2 whole cell lysateLane 1: Rabbit control IgG (1ug) instead of MBS1495644 in HepG2 whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the secondary antibody (1/50000)Lane 2:MBS1495644 (4ug)+HepG2 whole cell lysate (500ug)Lane 3:HepG2 whole cell lysate (20ug))
Immunoprecipitation (IP)
(Immunoprecipitating ZNF346 in HepG2 whole cell lysateLane 1: Rabbit control IgG (1ug) instead of MBS1495644 in HepG2 whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the secondary antibody (1/50000)Lane 2:MBS1495644 (4ug)+HepG2 whole cell lysate (500ug)Lane 3:HepG2 whole cell lysate (20ug))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Description
ZNF346: Binds to dsRNA and DNA. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleolus
Chromosomal Location of Human Ortholog: 5q35.2
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: double-stranded RNA binding; enzyme binding; p53 binding; protein binding; zinc ion binding
Biological Process: positive regulation of apoptosis
Research Articles on ZNF346
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Product Notes
The ZNF346 znf346 (Catalog #AAA1495644) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Zinc finger protein 346 polyclonal Antibody(ZNF346) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Zinc finger protein 346 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Recommended dilution: IHC:1:20-1:200. Researchers should empirically determine the suitability of the ZNF346 znf346 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Zinc finger protein 346, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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