Rabbit ZCRB1 Polyclonal Antibody | anti-ZCRB1 antibody

ZCRB1 Antibody

Cat. Num. AAA9405855

• Gene Names: ZCRB1; MADP1; RBM36; MADP-1; SNRNP31; ZCCHC19
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity chromatography purified via peptide column
• Synonyms: ZCRB1; Polyclonal Antibody; ZCRB1 Antibody; Zinc finger CCHC-type and RNA binding motif 1; ZCCHC19; MADP-1; RBM36; anti-ZCRB1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 217

• Applicable Applications for anti-ZCRB1 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 17 amino acid peptide near the carboxy terminus of human ZCRB1.
• Target Name: ZCRB1
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of ZCRB1 in Raji cell lysate with ZCRB1 antibody at (A) 1 and (B) 2 ug/mL.)

Related Product Information for anti-ZCRB1 antibody

ZCRB1 is a nuclear protein first identified in a differential display screen involving morphine-dependence-related genes. Its expression is increased following morphine treatment and has been observed to be elevated in HepG2 cells. ZCRB1 contains a CCHC-type zing finger RNA-binding motif and can interact with the DBA-binding domain of the stem cell regulator C/EBP transcription factors. ZCRB1 was identified as one of the protein components of U11/U12 snRNPs, which are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron, suggesting ZCRB1 may play a key role in U12-type splicing.

Product Categories/Family for anti-ZCRB1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 51243065
• NCBI GeneID: 85437
• NCBI Accession #: NP_149105
• NCBI GenBank Nucleotide #: NM_033114.3
• Molecular Weight: 24,592 Da
• NCBI Official Full Name: zinc finger CCHC-type and RNA-binding motif-containing protein 1
• NCBI Official Synonym Full Names: zinc finger CCHC-type and RNA binding motif 1
• NCBI Official Symbol: ZCRB1
• NCBI Official Synonym Symbols: MADP1; RBM36; MADP-1; SNRNP31; ZCCHC19
• NCBI Protein Information: zinc finger CCHC-type and RNA-binding motif-containing protein 1
• UniProt Protein Name: Zinc finger CCHC-type and RNA-binding motif-containing protein 1
• Protein Family: Zinc finger CCHC-type and RNA-binding motif-containing protein
• UniProt Gene Name: ZCRB1
• UniProt Synonym Gene Names: U11/U12 snRNP 31 kDa protein; U11/U12-31K
• UniProt Entry Name: ZCRB1_HUMAN

NCBI Description

Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]

Uniprot Description

ZCRB1: Up-regulated by morphine. Down-regulated at 30-36 degrees Celsius while it is up-regulated at 39 degrees Celsius. Component of the U11/U12 snRNPs that are part of the U12- type spliceosome.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: nucleoplasm; U12-dependent spliceosome

Molecular Function: zinc ion binding; nucleotide binding

Biological Process: RNA splicing; mRNA processing