Rabbit ZBTB5 Polyclonal Antibody | anti-ZBTB5 antibody

ZBTB5 Antibody

Cat. Num. AAA9411314

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: ZBTB5; Polyclonal Antibody; ZBTB5 Antibody; Zinc finger and BTB domain-containing protein 5; anti-ZBTB5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: At least two isoforms of ZBTB5 are known to exist; this antibody will recognize both isoforms. This antibody is predicted to not cross-react with other ZBTB protein family members.
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 677

• Applicable Applications for anti-ZBTB5 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 16 amino acid peptide near the carboxy terminus of human ZBTB6.
• Target Name: ZBTB5
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of ZBTB5 in mouse brain tissue lysate with ZBTB5 antibody at (A) 1 and (B) 2 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of ZBTB5 in human brain tissue with ZBTB5 antibody at 2.5 ug/mL.)

Related Product Information for anti-ZBTB5 antibody

The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB5 was identified though sequence analysis as a POZ domain Kruppel-like zinc finger (POK) protein. Further experiments indicated that it binds DNA and can directly repress transcription of the cell cycle arrest gene p21. ZBTB5 can also interact with co-repressor histone deacetylase complexes such as BCoR, NCoR, and SMRT via its POZ domain, resulting in deacetylation of histones Ac-H3 and Ac-H4 at the proximal promoter. ZBTB5 stimulates both cell proliferation and cell cycle progression, suggesting that it may act as a potential proto-oncogene.

Product Categories/Family for anti-ZBTB5 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 7662074
• NCBI GeneID: 9925
• NCBI Accession #: NP_055687
• NCBI GenBank Nucleotide #: NM_014872.2
• Molecular Weight: 74,278 Da
• NCBI Official Full Name: zinc finger and BTB domain-containing protein 5
• NCBI Official Synonym Full Names: zinc finger and BTB domain containing 5
• NCBI Official Symbol: ZBTB5
• NCBI Protein Information: zinc finger and BTB domain-containing protein 5
• UniProt Protein Name: Zinc finger and BTB domain-containing protein 5
• Protein Family: Zinc finger and BTB domain-containing protein
• UniProt Gene Name: ZBTB5
• UniProt Synonym Gene Names: KIAA0354
• UniProt Entry Name: ZBTB5_HUMAN

Uniprot Description

ZBTB5: May be involved in transcriptional regulation.

Protein type: DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 9p13.2

Cellular Component: nucleus

Molecular Function: DNA binding; metal ion binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent