Rabbit anti-Human, Mouse ZBTB7A Polyclonal Antibody | anti-ZBTB7A antibody

ZBTB7A Antibody

Cat. Num. AAA150670

• Gene Names: ZBTB7A; LRF; FBI1; FBI-1; ZBTB7; ZNF857A; pokemon
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: ZBTB7A Antibody is affinity chromatography purified via peptide column.
• Synonyms: ZBTB7A; Polyclonal Antibody; ZBTB7A Antibody; LRF; FBI1; FBI-1; ZBTB7; ZNF857A; pokemon; Zinc finger and BTB domain-containing protein 7A; Factor binding IST protein 1; zinc finger and BTB domain containing 7A; anti-ZBTB7A antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: At least two isoforms of ZBTB7A are known to exist; this antibody will recognize both isoforms. This antibody is predicted to not cross-react with other ZBTB protein family members.
• Purity/Purification: ZBTB7A Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 584

• Applicable Applications for anti-ZBTB7A antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: ZBTB7A antibody can be used for detection of ZBTB7A by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: ZBTB7A antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human ZBTB7A.
• Buffer: ZBTB7A Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: ZBTB7A antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of ZBTB7A in human ovary tissue lysate with ZBTB7A antibody at (A) 1 and (B) 2 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of ZBTB7A in human ovary tissue with ZBTB7A antibody at 2.5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of ZBTB7A in human ovary tissue with ZBTB7A antibody at 20 μg/mL.)

Related Product Information for anti-ZBTB7A antibody

ZBTB7A Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB7A, also known as LRF, was initially identified as a potential target of the LAZ-3/BCL-6 oncogene. Later reports demonstrated that it could bind to the wild-type IST (inducer of short transcripts) elements of HIV-1 long terminal repeats (LTRs) and stimulate Tat activity on the HIV-1 LTR. More recently it ZBTB7A has been recognized as a proto-oncogene whose overexpression contributes to malignancy in breast cancer and functions as a co-repressor of the androgen receptor in prostate cancer cells.

NCBI and Uniprot Product Information

• NCBI GI #: 7705375
• NCBI GeneID: 51341
• NCBI Accession #: AAH84568
• NCBI GenBank Nucleotide #: NM_015898.2
• UniProt Accession #: O95365; O00456; Q14D41; Q5XG86; D6W619
• Molecular Weight: 61,439 Da
• NCBI Official Full Name: zinc finger and BTB domain-containing protein 7A
• NCBI Official Synonym Full Names: zinc finger and BTB domain containing 7A
• NCBI Official Symbol: ZBTB7A
• NCBI Official Synonym Symbols: LRF; FBI1; FBI-1; ZBTB7; ZNF857A; pokemon
• NCBI Protein Information: zinc finger and BTB domain-containing protein 7A; TIP21; lymphoma related factor; zinc finger protein 857A; HIV-1 1st-binding protein 1; TTF-I-interacting peptide 21; factor binding IST protein 1; leukemia/lymphoma-related factor; POK erythroid myeloid ontogenic factor; HIV-1 inducer of short transcripts binding protein; POZ and Krueppel erythroid myeloid ontogenic factor; factor that binds to inducer of short transcripts protein 1; zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein
• UniProt Protein Name: Zinc finger and BTB domain-containing protein 7A
• Protein Family: Zinc finger and BTB domain-containing protein
• UniProt Gene Name: ZBTB7A
• UniProt Synonym Gene Names: FBI1; LRF; ZBTB7; ZNF857A; FBI-1; POK erythroid myeloid ontogenic factor; Pokemon; TIP21
• UniProt Entry Name: ZBT7A_HUMAN

Uniprot Description

FBI1: a widely expressed zinc finger protein. Apparently interacts with Bcl-6.

Protein type: Transcription factor; C2H2-type zinc finger protein; DNA-binding

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleus

Molecular Function: histone acetyltransferase binding; protein binding; DNA binding; metal ion binding

Biological Process: transcription, DNA-dependent; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; cell differentiation