Rabbit anti-Human, Mouse ZAK Polyclonal Antibody | anti-ZAK antibody

ZAK Polyclonal Antibody

Cat. Num. AAA2563119

• Gene Names: MAP3K20; pk; AZK; MLT; MRK; ZAK; CNM6; MLK7; MLTK; SFMMP; mlklak; MLTKbeta; MLTKalpha
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: ZAK; Polyclonal Antibody; ZAK Polyclonal Antibody; AZK; Cervical cancer suppressor gene 4 protein; HCCS 4; HCCS-4; HCCS4; Human cervical cancer suppressor gene 4 protein; Leucine zipper and sterile alpha motif containing kinase; Leucine zipper- and sterile alpha motif-containing kinase; Mitogen activated protein kinase kinase kinase MLT; Mitogen-activated protein kinase kinase kinase MLT; Mixed lineage kinase 7; Mixed lineage kinase related kinase; Mixed lineage kinase related kinase MRK beta; Mixed lineage kinase with a leucine zipper and a sterile alpha motif; Mixed lineage kinase-related kinase; MLK 7; MLK like mitogen activated protein triple kinase; MLK related kinase; MLK-like mitogen-activated protein triple kinase; MLK-related kinase; MLK7; Mlklak; MLT; MLTK; MRK; Sterile alpha motif and leucine zipper containing kinase AZK; Sterile alpha motif- and leucine zipper-containing kinase AZK; Zak; anti-ZAK antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 1.2mg/mL (varies by lot)
• Sequence Length: 800

• Applicable Applications for anti-ZAK antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50-1:200; ELISA: 1:2000-1:5000
• Immunogen: Synthetic peptide of human ZAK
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using ZAK Polyclonal Antibody at dilution of 1:100(×200))

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using ZAK Polyclonal Antibody at dilution of 1:100(×200))

Related Product Information for anti-ZAK antibody

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. 

Product Categories/Family for anti-ZAK antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 82880648
• NCBI GeneID: 51776
• NCBI Accession #: NP_057737.2
• NCBI GenBank Nucleotide #: NP_057737.2
• UniProt Accession #: Q9NYL2
• NCBI Official Full Name: mitogen-activated protein kinase kinase kinase 20 isoform 1
• NCBI Official Synonym Full Names: mitogen-activated protein kinase kinase kinase 20
• NCBI Official Symbol: MAP3K20
• NCBI Official Synonym Symbols: pk; AZK; MLT; MRK; ZAK; CNM6; MLK7; MLTK; SFMMP; mlklak; MLTKbeta; MLTKalpha
• NCBI Protein Information: mitogen-activated protein kinase kinase kinase 20
• UniProt Protein Name: Mitogen-activated protein kinase kinase kinase MLT
• Protein Family: Mitogen-activated protein kinase kinase kinase
• UniProt Gene Name: MLTK
• UniProt Synonym Gene Names: ZAK; HCCS-4; MLK-related kinase; MRK
• UniProt Entry Name: MLTK_HUMAN

NCBI Description

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

ZAK: a mixed-lineage kinase containing a leucine-zipper (LZ) and a sterile-alpha motif (SAM). It is reported to activate the JNK/SAPK and NF-kappaB pathways.

Protein type: EC 2.7.11.25; Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; MLK subfamily

Chromosomal Location of Human Ortholog: 2q24.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; magnesium ion binding; ATP binding

Biological Process: cell death; cell proliferation; response to radiation; activation of MAPKK activity; positive regulation of apoptosis; DNA damage checkpoint; response to stress; cytoskeleton organization and biogenesis; cell cycle arrest; cell differentiation; protein amino acid phosphorylation; cell cycle checkpoint; activation of JNK activity