Human Chemokine C-C-Motif Ligand 3 Like Protein 1 ELISA Kit | CCL3L1 elisa kit

Human Chemokine C-C-Motif Ligand 3 Like Protein 1 ELISA Kit

Cat. Num. AAA765598

• Gene Names: CCL3L3; LD78; 464.2; SCYA3L; G0S19-2; SCYA3L1; D17S1718; LD78BETA
• Reactivity: Human
• Synonyms: Chemokine C-C-Motif Ligand 3 Like Protein 1; Human Chemokine C-C-Motif Ligand 3 Like Protein 1 ELISA Kit; CCL3L1/G0S19-2/LD78 beta/SCYA3L1/chemokine (C-C motif) ligand 3-like 3; 464.2/chemokine (C-C motif) ligand 3-like; centromeric/G0/G1 switch regulatory protein 19-2/G0S19-2/LD78/LD78BETA/LD78-beta (1-70)/PAT 464.2/SCYA3L/SCYA3L1/small inducible cytokine A3-like 1/Small-inducible cytokine A3-like 1/Tonsillar lymphocyte LD78 beta protein; CCL3L1 elisa kit

• Reactivity: Human
• Sequence Length: 93

• Samples: Serum, plasma and other biological fluids.
• Assay Type: Sandwich ELISA, Double Antibody
• Detection Range: 78.125-5000pg/ml
• Sensitivity: 46.875pg/ml
• Preparation and Storage: Store at 4 degree C if kit is to be used within 1 week. Stable for 6 months (if micro ELISA Plate, Lyophilized Standard and Concentrated Biotinylated Detection Protein stored at-20 degree C. Other components at 2-8 degree C). Stable for 12 months (if the entire kit is stored at-20 degree C).

Typical Testing Data

Typical Standard Curve

Related Product Information for CCL3L1 elisa kit

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. anti-Human CCL3L1 antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Human CCL3L1 antibody was used as detection antibodies. The standards, test samples and biotin conjugated detection antibody were added to the wells subsequently, and wash with wash buffer. HRP-Streptavidin was added and unbound conjugates were washed away with wash buffer. TMB substrates were used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the Human CCL3L1 amount of sample captured in plate. Read the O.D. absorbance at 450nm in a microplate reader, and then the concentration of Human CCL3L1 can be calculated.

NCBI and Uniprot Product Information

• NCBI GI #: 93589094
• NCBI GeneID: 414062
• NCBI Accession #: NP_001001437.2
• NCBI GenBank Nucleotide #: NM_001001437.3
• Molecular Weight: 10,161 Da
• NCBI Official Full Name: C-C motif chemokine 3-like 1
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 3-like 3
• NCBI Official Symbol: CCL3L3
• NCBI Official Synonym Symbols: LD78; 464.2; SCYA3L; G0S19-2; SCYA3L1; D17S1718; LD78BETA
• NCBI Protein Information: C-C motif chemokine 3-like 1
• UniProt Protein Name: C-C motif chemokine 3-like 1
• Protein Family: C-C motif chemokine
• UniProt Gene Name: CCL3L1
• UniProt Synonym Gene Names: D17S1718; G0S19-2; SCYA3L1
• UniProt Entry Name: CL3L1_HUMAN

NCBI Description

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014]

Uniprot Description

CCL3L1: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1- infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q21.1

Cellular Component: extracellular region; extracellular space

Molecular Function: CCR chemokine receptor binding; chemokine activity

Biological Process: G-protein coupled receptor protein signaling pathway; inflammatory response; lymphocyte chemotaxis; monocyte chemotaxis; negative regulation of cell proliferation; neutrophil chemotaxis; positive regulation of GTPase activity; positive regulation of inflammatory response

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To