Rabbit anti-Human XPC Polyclonal Antibody | anti-XPC antibody

XPC Polyclonal Antibody

Cat. Num. AAA3009141

• Gene Names: XPC; XP3; RAD4; XPCC; p125
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: XPC; Polyclonal Antibody; XPC Polyclonal Antibody; XP3; RAD4; XPCC; p125; anti-XPC antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: XPC polyclonal antibody detects endogenous levels of XPC protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 940

• Applicable Applications for anti-XPC antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:100; IP: 1:50-1:100
• Immunogen: Recombinant protein of human XPC.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of various cell lines, using XPC antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver cancer using XPC antibody at dilution of 1:100 (40x lens).)

Related Product Information for anti-XPC antibody

This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 224809295
• NCBI GeneID: 7508
• NCBI Accession #: NP_004619.3
• NCBI GenBank Nucleotide #: NP_004619.3
• UniProt Accession #: Q01831
• Molecular Weight: ~ 130kDa
• NCBI Official Full Name: DNA repair protein complementing XP-C cells
• NCBI Official Synonym Full Names: XPC complex subunit, DNA damage recognition and repair factor
• NCBI Official Symbol: XPC
• NCBI Official Synonym Symbols: XP3; RAD4; XPCC; p125
• NCBI Protein Information: DNA repair protein complementing XP-C cells
• UniProt Protein Name: DNA repair protein complementing XP-C cells
• Protein Family: DNA repair protein
• UniProt Gene Name: XPC
• UniProt Synonym Gene Names: XPCC
• UniProt Entry Name: XPC_HUMAN

NCBI Description

The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]