Rabbit anti-Rat Xeroderma Pigmentosum, Complementation Group C (XPC) Polyclonal Antibody | anti-XPC antibody
Biotin-Linked Polyclonal Antibody to Xeroderma Pigmentosum, Complementation Group C (XPC)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]
Uniprot Description
XPC: a probable nuclear protein involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. Defects in XPC are a cause of xeroderma pigmentosum complementation group C.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 3p25.1
Cellular Component: cytoplasm; extracellular exosome; intracellular membrane-bound organelle; mitochondrion; nucleolus; nucleoplasm; nucleotide-excision repair factor 2 complex; nucleus; plasma membrane; XPC complex
Molecular Function: bubble DNA binding; damaged DNA binding; loop DNA binding; protein binding; single-stranded DNA binding
Biological Process: DNA repair; intra-S DNA damage checkpoint; mismatch repair; nucleotide-excision repair; nucleotide-excision repair, DNA damage recognition; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, preincision complex assembly; regulation of mitotic cell cycle phase transition; response to auditory stimulus; response to drug; response to UV-B
Disease: Xeroderma Pigmentosum, Complementation Group C
Research Articles on XPC
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Product Notes
The XPC xpc (Catalog #AAA2092043) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Biotin-Linked Polyclonal Antibody to Xeroderma Pigmentosum, Complementation Group C (XPC) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Xeroderma Pigmentosum, Complementation Group C (XPC) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the XPC xpc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Xeroderma Pigmentosum, Complementation Group C (XPC), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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