Rabbit anti-Human, Mouse 4E-T Polyclonal Antibody | anti-4E-T antibody

Anti-4E-T Antibody

Cat. Num. AAA8306557

• Gene Names: EIF4ENIF1; 4E-T; Clast4
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Immunogen Affinity Chromatography
• Synonyms: 4E-T; Polyclonal Antibody; Anti-4E-T Antibody; Eukaryotic translation initiation factor 4E transporter; eIF4E transporter; Eukaryotic translation initiation factor 4E nuclear import factor 1; anti-4E-T antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of 4E-T protein.
• Purity/Purification: Purified by Immunogen Affinity Chromatography
• Form/Format: Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.

• Applicable Applications for anti-4E-T antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: KLH-conjugated synthetic peptide of human 4E-T. The exact sequence is proprietary.
• Preparation and Storage: Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of 4E-T expression in HeLa (A), HT29 (B) whole cell lysates.)

Related Product Information for anti-4E-T antibody

Rabbit polyclonal antibody to 4E-T

NCBI and Uniprot Product Information

• NCBI GI #: 33877833
• NCBI GeneID: 56478
• UniProt Accession #: Q9NRA8; Q9EST3
• Molecular Weight: 108,201 Da
• NCBI Official Full Name: EIF4ENIF1 protein, partial
• NCBI Official Synonym Full Names: eukaryotic translation initiation factor 4E nuclear import factor 1
• NCBI Official Symbol: EIF4ENIF1
• NCBI Official Synonym Symbols: 4E-T; Clast4
• NCBI Protein Information: eukaryotic translation initiation factor 4E transporter; 2610509L04Rik; eIF4E transporter; eIF4E-transporter
• UniProt Protein Name: Eukaryotic translation initiation factor 4E transporter
• UniProt Gene Name: EIF4ENIF1
• UniProt Synonym Gene Names: 4E-T
• UniProt Entry Name: 4ET_HUMAN

NCBI Description

The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Uniprot Description

Function: Nucleoplasmic shuttling protein. Mediates the nuclear import of EIF4E by a piggy-back mechanism.

Subunit structure: Interacts with EIF4E. Interacts with importin beta only in the presence of importin alpha, suggesting a direct interaction with importin alpha. Interacts with APOBEC3G in an RNA-dependent manner. Ref.7

Subcellular location: Cytoplasm. Nucleus. Nucleus › PML body. Nucleus speckle. Note: Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription. Ref.16

Tissue specificity: Widely expressed.

Sequence caution: The sequence BAB15092.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC11194.1 differs from that shown. Reason: Erroneous initiation.