Western Blot (WB)
(WWOX Antibody (C-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the WWOX antibody detected the WWOX protein (arrow).)
Rabbit anti-Mouse WWOX Polyclonal Antibody | anti-WWOX antibody
WWOX Antibody (C-term)
Western Blot (WB)
(WWOX Antibody (C-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the WWOX antibody detected the WWOX protein (arrow).)
Western Blot (WB)
(WWOX Antibody (C-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the WWOX antibody detected the WWOX protein (arrow).)
and play an important role in the regulation of a wide variety of
cellular functions such as protein degradation, transcription, and
RNA splicing. This gene encodes a protein which contains 2 WW
domains and a short-chain dehydrogenase/reductase domain (SRD). The
highest normal expression of this gene is detected in hormonally
regulated tissues such as testis, ovary, and prostate. This
expression pattern and the presence of an SRD domain suggest a role
for this gene in steroid metabolism. The encoded protein is more
than 90% identical to the mouse protein, which is an essential
mediator of tumor necrosis factor-alpha-induced apoptosis,
suggesting a similar, important role in apoptosis for the human
protein. In addition, there is evidence that this gene behaves as a
suppressor of tumor growth. Alternative splicing of this gene
generates transcript variants that encode different isoforms.
Baykara, O., et al. Tumour Biol. 31(4):315-320(2010)
Kurek, K.C., et al. Cancer Res. 70(13):5577-5586(2010)
Lin, J., et al. Zhonghua Gan Zang Bing Za Zhi 18(5):357-360(2010)
Saez, M.E., et al. BMC Med. Genet. 11, 148 (2010) :
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Description
WWOX: an enzyme which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). Expressed at high levels in hormonally regulated tissues such as testis, ovary, and prostate. Its SRD domain suggest a role for this gene in steroid metabolism. Shown to be an essential mediator of tumor necrosis factor-alpha-induced apoptosis in the mouse. May play a similar role in the human. May function as a suppressor of tumor growth. Alternative splicing of this gene generates 7 isoforms.
Protein type: Oxidoreductase; Apoptosis; EC 1.1.1.-; Tumor suppressor
Chromosomal Location of Human Ortholog: 16q23
Cellular Component: Golgi apparatus; microvillus; mitochondrion; cytoplasm; plasma membrane; nucleus; cytosol
Molecular Function: protein dimerization activity; protein binding; enzyme binding; oxidoreductase activity; cofactor binding; coenzyme binding
Biological Process: steroid metabolic process; osteoblast differentiation; negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; skeletal morphogenesis; positive regulation of transcription from RNA polymerase II promoter
Disease: Epileptic Encephalopathy, Early Infantile, 28
Research Articles on WWOX
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Product Notes
The WWOX wwox (Catalog #AAA9206563) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 369-396. The WWOX Antibody (C-term) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's WWOX can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the WWOX wwox for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "WWOX, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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