Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using WAPL Antibody at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200))
Rabbit anti-Human, Mouse WAPL Polyclonal Antibody | anti-WAPL antibody
WAPL Antibody
Gene Names
WAPL; FOE; WAPAL; KIAA0261
Reactivity
Human, Mouse
Applications
Immunohistochemistry
Purity
Antigen affinity purification
Synonyms
WAPL; Polyclonal Antibody; WAPL Antibody; FOE; WAPAL; KIAA0261; anti-WAPL antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total WAPL protein.
Purity/Purification
Antigen affinity purification
Form/Format
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Concentration
0.9mg/ml (varies by lot)
Sequence Length
1184
Applicable Applications for anti-WAPL antibody
Immunohistochemistry (IHC)
Application Notes
Immunohistochemistry: 1: 20-100
Immunogen
Synthetic peptide of human WAPL
Immunogen Type
Peptide
Preparation and Storage
Store at -20 degree C
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using WAPL Antibody at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using WAPL Antibody at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using WAPL Antibody at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using WAPL Antibody at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200))
Related Product Information for anti-WAPL antibody
WAPL (wings apart-like), also known as WAPAL or FOE, is a 1,190 amino acid protein that contains one WAPL domain and is expressed as two alternatively spliced isoforms, one of which localizes to the nucleus. Expressed in an isoform-dependent manner in heart, skeletal muscle and uterine cervix tumor tissue, WAPL is involved in sister-chromatid adhesion and overall cell growth, specifically playing a role in the development and metastasis of cancerous tissue. The gene encoding WAPL maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman¡¯s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
Product Categories/Family for anti-WAPL antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
142,525 Da
NCBI Official Full Name
wings apart-like protein homolog isoform 2
NCBI Official Synonym Full Names
WAPL cohesin release factor
NCBI Official Symbol
WAPL
NCBI Official Synonym Symbols
FOE; WAPAL; KIAA0261
NCBI Protein Information
wings apart-like protein homolog
UniProt Protein Name
Wings apart-like protein homolog
Protein Family
UniProt Gene Name
WAPL
UniProt Entry Name
WAPL_HUMAN
Uniprot Description
WAPL: a chromatin-associated protein partner of Epstein-Barr nuclear protein 2. Associated with cervical carcinogenesis and tumor progression.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 10q23.2
Cellular Component: chromatin; chromosome; chromosome, pericentric region; cohesin complex; cytoplasm; cytosol; intracellular membrane-bound organelle; microtubule cytoskeleton; nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: meiotic chromosome segregation; mitotic sister chromatid cohesion; negative regulation of DNA replication; negative regulation of sister chromatid cohesion; sister chromatid cohesion
Research Articles on WAPL
Similar Products
Product Notes
The WAPL wapl (Catalog #AAA9417066) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The WAPL Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's WAPL can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1: 20-100. Researchers should empirically determine the suitability of the WAPL wapl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "WAPL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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