Western Blot (WB)
(Anti-VGF antibody, MBS176200, Western blottingLane 1: Rat Brain TissueLane 2: U87 Cell LysateLane 3: U87 Cell LysateLane 4: SHG Cell LysateLane 5: NEURO Cell Lysate )
Rabbit VGF Polyclonal Antibody | anti-VGF antibody
Anti-VGF antibody
Western Blot (WB)
(Anti-VGF antibody, MBS176200, Western blottingLane 1: Rat Brain TissueLane 2: U87 Cell LysateLane 3: U87 Cell LysateLane 4: SHG Cell LysateLane 5: NEURO Cell Lysate )
Western Blot (WB)
(Anti-VGF antibody, MBS176200, Western blottingLane 1: Rat Brain TissueLane 2: U87 Cell LysateLane 3: U87 Cell LysateLane 4: SHG Cell LysateLane 5: NEURO Cell Lysate )
Background: VGF(VGF, Nerve Growth Factor-Inducible), is a protein and neuropeptide that may play a role in regulating energy homeostasis, metabolism. Canu et al.(1997) noted that rat Vgf encodes a predicted 70-kD polypeptide that shares similarities with the secretogranin/chromogranin family and is found in the secretory granules of subsets of neurons and endocrine cells. By fluorescence in situ hybridization, Canu et al.(1997) assigned the VGF gene to 7q22. Canu et al.(1997) demonstrated that the single-copy human VGF gene spans 6 kb of genomic DNA and contains 2 exons. The entire VGF protein is encoded by exon 2, while exon 1 contains only 5-prime untranslated sequence. The structural organization of the human gene is similar to that described for the rat VGF gene(Salton et al., 1991), and both the translated and the untranslated regions show a high degree of sequence homology to the rat gene.
NCBI and Uniprot Product Information
NCBI Description
This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]
Uniprot Description
VGF: May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: extracellular space; transport vesicle; cytoplasmic vesicle
Molecular Function: neuropeptide hormone activity; growth factor activity
Biological Process: response to dietary excess; generation of precursor metabolites and energy; response to cAMP; ovarian follicle development; insulin secretion; sexual reproduction; defense response to bacterium; response to cold; glucose homeostasis; response to insulin stimulus
Research Articles on VGF
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Product Notes
The VGF vgf (Catalog #AAA176200) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-VGF antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's VGF can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the VGF vgf for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VGF, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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