Rabbit VEGFB Polyclonal Antibody | anti-VEGFB antibody

VEGFB Antibody HRP Conjugated

Cat. Num. AAA9460163

• Gene Names: NRTN; NTN
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Purified by Protein A
• Synonyms: VEGFB; Polyclonal Antibody; VEGFB Antibody HRP Conjugated; Vascular endothelial growth factor B; VEGF B; VEGF-B; VEGF related factor; VEGFL; Vrf; vascular endothelial growth factor B isoform VEGFB-167 precursor; VEGFB_HUMAN; anti-VEGFB antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A
• Form/Format: 10mM Tris Buffered Saline containing 1% BSA, 50% glycerol and 0.09% Gentamicin.
• Concentration: 1mgml (varies by lot)

• Applicable Applications for anti-VEGFB antibody: Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: WB: 1:100-1000; IHC: 1:100-500
• Conjugation: HRP
• Immunogen: KLH conjugated synthetic peptide derived from human VEGFB
• Preparation and Storage: Store at 4 degree C for 12 months.

Related Product Information for anti-VEGFB antibody

The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described and include fibroblast growth factor (FGF), platelet derived growth factor (PDGF) and vascular endothelial growth factors (VEGFs). The VEGF protein family is comprised of VEGF, VEGF-B, VEGF-C and VEGF-D, all of which may exhibit angiogenic function in vivo. VEGF-B, which exists as two alternatively spliced isoforms known as VEGF-B167 and VEGF-B186, is abundantly expressed in heart and skeletal muscle and is frequently co-expressed with VEGF. VEGF-C binds to and specifically activates Flt-4 and Flk-1.

Product Categories/Family for anti-VEGFB antibody

Conjugated Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 4758826
• NCBI GeneID: 4902
• NCBI Accession #: NP_004549.1
• NCBI GenBank Nucleotide #: NM_004558.3
• UniProt Accession #: Q99748; B2RPE8
• Molecular Weight: 22,405 Da
• NCBI Official Full Name: neurturin preproprotein
• NCBI Official Synonym Full Names: neurturin
• NCBI Official Symbol: NRTN
• NCBI Official Synonym Symbols: NTN
• NCBI Protein Information: neurturin; prepro-neurturin
• UniProt Protein Name: Neurturin
• Protein Family: Vascular endothelial growth factor
• UniProt Gene Name: NRTN
• UniProt Entry Name: NRTN_HUMAN

NCBI Description

Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Jul 2008]

Uniprot Description

NRTN: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Belongs to the TGF-beta family. GDNF subfamily.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: axon; extracellular region

Molecular Function: growth factor activity; receptor binding

Biological Process: nervous system development; axon guidance; MAPKKK cascade; nerve development; neural crest cell migration; neurite development; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Hirschsprung Disease, Susceptibility To, 1