Rabbit anti-Mouse VANGL2 Polyclonal Antibody | anti-VANGL2 antibody

VANGL2, NT (VANGL2, KIAA1215, STB1, Vang-like protein 2, Loop-tail protein 1 homolog, Strabismus 1, Van Gogh-like protein 2)

Cat. Num. AAA643360

• Gene Names: VANGL2; LPP1; LTAP; STB1; STBM; STBM1
• Reactivity: Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: VANGL2; Polyclonal Antibody; NT (VANGL2; KIAA1215; STB1; Vang-like protein 2; Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2); Anti -VANGL2; anti-VANGL2 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Mouse
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-VANGL2 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: VANGL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human VANGL2.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(VANGL2 Antibody (N-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the VANGL2 antibody detected the VANGL2 protein (arrow).)

Related Product Information for anti-VANGL2 antibody

Planar cell polarity (PCP) is the term given to global cell polarization, such as the alignment of mammalian body hair along the anterior-posterior axis or the orientation of steriocilia bundles in the inner ear. VANGL2 is a PCP protein that is involved in the transmission of directional cues to align either individual cells within an epithelial sheet or multicellular clusters, which polarize as a group (Devenport and Fuchs, 2008 [PubMed 18849982]).

Product Categories/Family for anti-VANGL2 antibody

Antibodies; Abs to KIAA; orf

NCBI and Uniprot Product Information

• NCBI GI #: 62955805
• NCBI GeneID: 57216
• NCBI Accession #: NP_065068.1
• NCBI GenBank Nucleotide #: NM_020335.2
• UniProt Accession #: Q9ULK5; Q5T212; D3DVE9
• Molecular Weight: 59,714 Da
• NCBI Official Full Name: vang-like protein 2
• NCBI Official Synonym Full Names: VANGL planar cell polarity protein 2
• NCBI Official Symbol: VANGL2
• NCBI Official Synonym Symbols: LPP1; LTAP; STB1; STBM; STBM1
• NCBI Protein Information: vang-like protein 2; strabismus 1; van Gogh-like protein 2; loop-tail protein 1 homolog; loop-tail-associated protein; vang-like 2 (van gogh, Drosophila)
• UniProt Protein Name: Vang-like protein 2
• Protein Family: Vang-like protein
• UniProt Gene Name: VANGL2
• UniProt Synonym Gene Names: KIAA1215; STB1
• UniProt Entry Name: VANG2_HUMAN

NCBI Description

The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]

Uniprot Description

VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family.

Protein type: Membrane protein, multi-pass; Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q22-q23

Cellular Component: basolateral plasma membrane; apical plasma membrane; stress fiber; plasma membrane; integral to membrane; intercellular junction; ER to Golgi transport vesicle; lateral plasma membrane

Biological Process: positive regulation of JNK activity; convergent extension involved in axis elongation; wound healing; convergent extension involved in neural plate elongation; somatic stem cell maintenance; regulation of Wnt receptor signaling pathway; digestive tract morphogenesis; glomerulus development; Rho protein signal transduction; establishment and/or maintenance of epithelial cell polarity; anterior/posterior pattern formation; inner ear receptor stereocilium organization and biogenesis; apical protein localization; hair follicle development; sensory cilium biogenesis; regulation of actin cytoskeleton organization and biogenesis; establishment of body hair orientation; neural tube closure; somatic stem cell division; establishment of planar polarity; heart looping

Disease: Neural Tube Defects