Rabbit anti-Mouse VANGL2 Polyclonal Antibody | anti-VANGL2 antibody

VANGL2, NT (VANGL2, KIAA1215, STB1, Vang-like protein 2, Loop-tail protein 1 homolog, Strabismus 1, Van Gogh-like protein 2) (PE)

Cat. Num. AAA6362234

• Gene Names: VANGL2; LPP1; LTAP; STB1; STBM; STBM1
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: VANGL2; Polyclonal Antibody; NT (VANGL2; KIAA1215; STB1; Vang-like protein 2; Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2) (PE); Van Gogh-like protein 2; anti-VANGL2 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-VANGL2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: VANGL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human VANGL2.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(VANGL2 Antibody (N-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the VANGL2 antibody detected the VANGL2 protein (arrow).)

Related Product Information for anti-VANGL2 antibody

Planar cell polarity (PCP) is the term given to global cell polarization, such as the alignment of mammalian body hair along the anterior-posterior axis or the orientation of steriocilia bundles in the inner ear. VANGL2 is a PCP protein that is involved in the transmission of directional cues to align either individual cells within an epithelial sheet or multicellular clusters, which polarize as a group (Devenport and Fuchs, 2008 [PubMed 18849982]).

Product Categories/Family for anti-VANGL2 antibody

Antibodies; KIAA; orf

References

Lei, Y.P., et al. N. Engl. J. Med. 362(23):2232-2235(2010). Yates, L.L., et al. Hum. Mol. Genet. 19(11):2251-2267(2010). Cantrell, V.A., et al. Cancer Lett. 287(1):54-61(2010). Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009). Devenport, D., et al. Nat. Cell Biol. 10(11):1257-1268(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 62955805
• NCBI GeneID: 57216
• NCBI Accession #: NP_065068.1
• NCBI GenBank Nucleotide #: NM_020335.2
• UniProt Accession #: Q9ULK5; Q5T212; D3DVE9
• NCBI Official Full Name: vang-like protein 2
• NCBI Official Synonym Full Names: VANGL planar cell polarity protein 2
• NCBI Official Symbol: VANGL2
• NCBI Official Synonym Symbols: LPP1; LTAP; STB1; STBM; STBM1
• NCBI Protein Information: vang-like protein 2
• UniProt Protein Name: Vang-like protein 2
• Protein Family: Vang-like protein
• UniProt Gene Name: VANGL2
• UniProt Synonym Gene Names: KIAA1215; STB1
• UniProt Entry Name: VANG2_HUMAN

NCBI Description

The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]