Immunohistochemistry (IHC)
(Immunochemical staining of human UVSSA in human liver with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human UVSSA Polyclonal Antibody | anti-UVSSA antibody
Anti-UVSSA Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
UVSSA; Polyclonal Antibody; Anti-UVSSA Antibody; Rabbit Polyclonal; UVSSA Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-KIAA1530 Antibody; Anti-UVSS3 Antibody; anti-UVSSA antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human UVSSA
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-UVSSA antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:200-1:1000
Immunogen
E Coli-derived Human UVSSA fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human UVSSA fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human UVSSA in human liver with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human UVSSA in human liver with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-UVSSA antibody
UV-stimulated scaffold protein A (UVSSA) consists of 709 amino acid residues. UVSSA contains a Vps27/Hrs/STAM (VHS) domain and a conserved domain of unknown function (DUF) 2043 in the N-terminal and C-terminal regions, respectively. After UV irradiation, UVSSA stabilizes CSB and restores the hypophosphorylated form of Pol II (Pol IIa) in collaboration with USP7. UVSSA forms a complex with ubiquitin-specific peptidase 7 (USP7) and is stabilized by interaction with USP7. The central region of UVSSA, which contains the tumor necrosis factor receptor-associated factor (TRAF)-binding motif, is required for the interaction with the N-terminal TRAF domain of USP7.
References
Wienholz F, et al. (2019) Fact subunit spt16 controls uvssa recruitment to lesion-stalled rna pol ii and stimulates tc-ner. Nucleic Acids Res 47 (8): 4011-4025.Schwertman P, et al. (2013) Uvssa and usp7, a new couple in transcription-coupled DNA repair. Chromosoma 122 (4): 275-284.Higa M, et al. (2018) Inhibition of uvssa ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from usp7. Febs j 285 (5): 965-976.
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Product Notes
The UVSSA (Catalog #AAA8109939) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-UVSSA Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's UVSSA can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:200-1:1000. Researchers should empirically determine the suitability of the UVSSA for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "UVSSA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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