Uteroglobin (SCGB1A1) Recombinant Protein | SCGB1A1 recombinant protein

Uteroglobin (SCGB1A1)

Cat. Num. AAA517777

• Gene Names: SCGB1A1; UGB; UP1; CC10; CC16; CCSP; UP-1; CCPBP
• Applications: Cell Assay
• Synonyms: Uteroglobin (SCGB1A1); Clara cell phospholipid-binding protein; CCPBP; Clara cells 10kDa secretory protein; CC10; Secretoglobin family 1A member 1; Urinary protein 1; Urine protein 1; UP1; SCGB1A1 recombinant protein

• Host: E Coli
• Form/Format: Lyophilized from a 0.2 um filtered solution in PBS

• Applicable Applications for SCGB1A1 recombinant protein: Cell Assay
• Species: Human
• Endotoxin Level: <1.0EU/ug of recombinant protein as determined by the LAL method.
• Reconstitution: Reconstitute at 100ug/mL in sterile PBS
• Preparation and Storage: The lyophilized protein is stable for at least one year from date of receipt at -70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree -8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

SDS-Page

(Purity: Recombinant Human Uteroglobin (SCGB1A1) resolved on a 17% SDS_PAGE gel under reducing conditions and stained with Coomassie Brilliant Blue G-250)

Related Product Information for SCGB1A1 recombinant protein

Recombinant Human Uteroglobin (SCGB1A1) was expressed in E Coli cells. The protein accession number is P11684
UP1 is a non-glycosylated secretoglobin family member protein which induces anti-inflammatory and anti-tumorigenic responses. The expression of Uteroglobin is induced by steroid hormones such as estrogen which is further enhanced by the non-steroid hormone prolactin. UP1 has been shown to induce growth stimulatory effects, sequester pro-inflammatory mediators and carcinogens and inhibit cell migration, cell invasion, platelet aggregation and T cell differentiation.

Product Categories/Family for SCGB1A1 recombinant protein

Growth Factors; Cancer

NCBI and Uniprot Product Information

• NCBI GI #: 112672
• NCBI GeneID: 7356
• UniProt Accession #: P11684; Q6FHH3; Q9UCM2; Q9UCM4; B2R5F2
• Molecular Weight: 91
• NCBI Official Full Name: Uteroglobin
• NCBI Official Synonym Full Names: secretoglobin, family 1A, member 1 (uteroglobin)
• NCBI Official Symbol: SCGB1A1
• NCBI Official Synonym Symbols: UGB; UP1; CC10; CC16; CCSP; UP-1; CCPBP
• NCBI Protein Information: uteroglobin; blastokinin; urine protein 1; urinary protein 1; clara cells 10 kDa secretory protein; clara cell phospholipid-binding protein
• UniProt Protein Name: Uteroglobin
• Protein Family: Uteroglobin
• UniProt Gene Name: SCGB1A1
• UniProt Synonym Gene Names: CC10; CCSP; UGB; CCPBP; CC10; UP-1; UP1; Urine protein 1
• UniProt Entry Name: UTER_HUMAN

NCBI Description

This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]

Uniprot Description

SCGB1A1: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. Belongs to the secretoglobin family.

Protein type: Secreted; Cell cycle regulation; Secreted, signal peptide; Inhibitor

Chromosomal Location of Human Ortholog: 11q12.3

Cellular Component: extracellular space; rough endoplasmic reticulum; nuclear envelope; secretory granule

Molecular Function: protein binding; phospholipase A2 inhibitor activity

Biological Process: response to drug; negative regulation of interleukin-4 production; response to glucocorticoid stimulus; response to lipopolysaccharide; female pregnancy; negative regulation of transcription from RNA polymerase II promoter; signal transduction; regulation of mRNA stability; response to xenobiotic stimulus; response to silicon dioxide; negative regulation of interleukin-13 production; negative regulation of T cell proliferation; response to ozone; negative regulation of interferon-gamma production; response to cytokine stimulus; negative regulation of catalytic activity; regulation of inflammatory response; negative regulation of interleukin-5 production; embryo implantation

Disease: Asthma, Susceptibility To