Rabbit Uracil DNA Glycosylase Polyclonal Antibody | anti-UNG antibody
Uracil DNA Glycosylase, CT (UDG, UNG, Uracil DNA Glycosylase 1, UNG 1, UNG1, UNG-1, Uracil DNA Glycosylase 2, DGU, DKFZp781L1143, HIGM4, UNG15)
Gene Names
UNG; ATUNG; UNG; uracil dna glycosylase
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
Uracil DNA Glycosylase; Polyclonal Antibody; CT (UDG; UNG; Uracil DNA Glycosylase 1; UNG 1; UNG1; UNG-1; Uracil DNA Glycosylase 2; DGU; DKFZp781L1143; HIGM4; UNG15); Anti -Uracil DNA Glycosylase; anti-UNG antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human uracil-DNA glycosylase 1 (UNG1). Species Crossreactivity: mouse, rat.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Applicable Applications for anti-UNG antibody
Western Blot (WB)
Application Notes
Suitable for use in Western Blot.
Dilution: Western Blot: 0.5-1ug/ml
Dilution: Western Blot: 0.5-1ug/ml
Immunogen
14 amino acid peptide sequence near the amino terminus of human UNG1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-UNG antibody
UNG1 is a member of the uracil-DNA glycosylase and cyclin family. Two isoforms of UNG exist, isoform 1 is expressed in the mitochondria of in skeletal muscle, heart and testicles while isoform 2 (UNG2) is more abundant in proliferating tissues and expressed in the nucleus.
Uracil residues can be misincorporated into DNA by DNA polymerase or by deamination of cytosine. UNG1 is a major enzyme in base excision repair, excising the misincorporated uracil residues in a process crucial to increasing immunoglobulin diversity. In association with activation-induced cytosine deaminase, UNG is also essential to the generation of strand breaks that initiate class switch recombination.
UNG is also involved in the innate immune response against retroviral infections, HIV-1 accessory protein Vpr induces the rapid degradation of UNG2.
Uracil residues can be misincorporated into DNA by DNA polymerase or by deamination of cytosine. UNG1 is a major enzyme in base excision repair, excising the misincorporated uracil residues in a process crucial to increasing immunoglobulin diversity. In association with activation-induced cytosine deaminase, UNG is also essential to the generation of strand breaks that initiate class switch recombination.
UNG is also involved in the innate immune response against retroviral infections, HIV-1 accessory protein Vpr induces the rapid degradation of UNG2.
Product Categories/Family for anti-UNG antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
36,289 Da
NCBI Official Full Name
uracil dna glycosylase
NCBI Official Symbol
UNG
NCBI Official Synonym Symbols
ATUNG; UNG; uracil dna glycosylase
NCBI Protein Information
uracil dna glycosylase
UniProt Protein Name
At3g18630
Protein Family
UniProt Gene Name
UNG
UniProt Entry Name
Q9LIH6_ARATH
NCBI Description
Encodes a uracil-DNA glycosylase (UDG) involved in a base excision DNA repair pathway in mitochondria.
Uniprot Description
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. More active on U:G, U:T and U:C mispairs than on U:A pairs. Highly specific for uracil and no activity with 5-substituted uracil or cytosine derivatives. Required for initiation of base excision repair (BER) of uracil.
Research Articles on UNG
Similar Products
Product Notes
The UNG ung (Catalog #AAA6008434) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Uracil DNA Glycosylase, CT (UDG, UNG, Uracil DNA Glycosylase 1, UNG 1, UNG1, UNG-1, Uracil DNA Glycosylase 2, DGU, DKFZp781L1143, HIGM4, UNG15) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Uracil DNA Glycosylase can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Dilution: Western Blot: 0.5-1ug/ml. Researchers should empirically determine the suitability of the UNG ung for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Uracil DNA Glycosylase, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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