Rabbit anti-Rat uPAR Polyclonal Antibody | anti-uPAR antibody

uPAR Antibody

Cat. Num. AAA841353

• Gene Names: Plaur; Par; uPAR; Plaur3; uPAR-2; uPAR-3
• Reactivity: Rat
• Applications: Western Blot
• Purity: Affinity purified
• Synonyms: uPAR; Polyclonal Antibody; uPAR Antibody; Urokinase plasminogen activator receptor; PLAUR; CD87; MO3; UPAR; URKR; Urokinase plasminogen activator surface receptor; U-PAR; Monocyte activation antigen Mo3; CD_antigen; anti-uPAR antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: 100 ug (0.5 mg/ml) affinity purified rabbit polyclonal antibody in 1X phosphate-buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.; Appearance: Colorless liquid
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 328

• Applicable Applications for anti-uPAR antibody: Western Blot (WB)
• Application Notes: Western blotting (0.5-1 ug/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 33 kDa rat uPAR. Reactivity to other species has not been tested.
• Immunogen: Synthetic peptide surrounding amino acid 51 of rat uPAR
• Handling: The antibody solution should be gently mixed before use.
• Preparation and Storage: At -20 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for anti-uPAR antibody

Background: uPAR (Urokinase plasminogen activator receptor) is a 55 kDa glycoprotein I-anchored surface receptor specific for urokinase plasminogen activator (uPA). Upon binding to uPAR, uPA converts the surface bound, large serum beta-globulin, plasminogen to plasmin. Plasmin, which is also designated fibrinolysin, is a trypsin-like enzyme that acts on Arg-Lys bonds and induces pericellular proteolysis in fibrin and fibrinogen, and thereby contributes to the systematic activation of the coagulation cascade. uPA and uPAR are known to be overexpressed in mesenchymal and epithelial tumor cells and are required for tumor invasion and metastasis.

NCBI and Uniprot Product Information

• NCBI GI #: 8394516
• NCBI GeneID: 50692
• NCBI Accession #: NP_059046.1
• NCBI GenBank Nucleotide #: NM_017350.1
• UniProt Accession #: P49616; O35771; P51573; Q7TN35
• Molecular Weight: 24,417 Da
• NCBI Official Full Name: urokinase plasminogen activator surface receptor isoform 2
• NCBI Official Synonym Full Names: plasminogen activator, urokinase receptor
• NCBI Official Symbol: Plaur
• NCBI Official Synonym Symbols: Par; uPAR; Plaur3; uPAR-2; uPAR-3
• NCBI Protein Information: urokinase plasminogen activator surface receptor
• UniProt Protein Name: Urokinase plasminogen activator surface receptor
• UniProt Gene Name: Plaur
• UniProt Synonym Gene Names: U-PAR; uPAR
• UniProt Entry Name: UPAR_RAT

NCBI Description

receptor for urokinase-plasminogen activator; may play a central role in malignant tumour progression [RGD, Feb 2006]

Uniprot Description

uPAR: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, GPI anchor; Motility/polarity/chemotaxis

Cellular Component: focal adhesion; integral to plasma membrane; extracellular region; plasma membrane

Molecular Function: protein domain specific binding; enzyme binding; U-plasminogen activator receptor activity; receptor binding

Biological Process: mesenchymal cell differentiation; skeletal muscle regeneration; spermatogenesis; negative regulation of apoptosis