Western Blot (WB)
(Western Blot analysis of UMPS in Human fetal liver tissue lysate using UMPS Rabbit pAb at dilution 1/400)
Rabbit anti-Human, Mouse UMPS Polyclonal Antibody | anti-UMPS antibody
UMPS Rabbit pAb
IHC-P: 1:30-1:150
Western Blot (WB)
(Western Blot analysis of UMPS in Human fetal liver tissue lysate using UMPS Rabbit pAb at dilution 1/400)
Western Blot (WB)
(Western Blot analysis of UMPS in Human fetal liver tissue lysate using UMPS Rabbit pAb at dilution 1/400)
Immunohistochemistry (IHC)
(Immunohistochemistry of UMPS in paraffin-embedded Human brain tissue using UMPS Rabbit pAb at dilution 1/40. Predicted cell location: Cytoplasm and Cell membrane)
Immunohistochemistry (IHC)
(Immunohistochemistry of UMPS in paraffin-embedded Human brain tissue using UMPS Rabbit pAb at dilution 1/40. Predicted cell location: Cytoplasm and Cell membrane)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Uniprot Description
UMPS: Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1). A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 4.1.1.23; Transferase; Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - pyrimidine; EC 2.4.2.10; Lyase
Chromosomal Location of Human Ortholog: 3q13
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: orotate phosphoribosyltransferase activity; orotidine-5'-phosphate decarboxylase activity
Biological Process: lactation; 'de novo' pyrimidine base biosynthetic process; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; UMP biosynthetic process; pyrimidine nucleoside biosynthetic process; female pregnancy
Disease: Orotic Aciduria
Research Articles on UMPS
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Product Notes
The UMPS umps (Catalog #AAA4760247) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The UMPS Rabbit pAb reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's UMPS can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:500-1:2000 IHC-P: 1:30-1:150. Researchers should empirically determine the suitability of the UMPS umps for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "UMPS, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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