Goat anti-Rat Ugt2b Polyclonal Antibody | anti-UGT2B7 antibody

Ugt2b (UDP Glycosyltransferase 2 Family Polypeptide B)

Cat. Num. AAA6003562

• Gene Names: UGT2B7; UGT2B9; UDPGTH2; UDPGT2B7; UDPGT 2B9
• Reactivity: Rat
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Ugt2b; Polyclonal Antibody; Ugt2b (UDP Glycosyltransferase 2 Family Polypeptide B); Anti -Ugt2b (UDP Glycosyltransferase 2 Family Polypeptide B); anti-UGT2B7 antibody

• Host: Goat
• Reactivity: Rat
• Clonality: Polyclonal
• Specificity: Recognizes rat Ugt2b.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

• Applicable Applications for anti-UGT2B7 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:32,000; Western Blot: 0.1-0.3ug/ml, observed in rat kidney lysates on ~50kD bands
• Immunogen: Synthetic peptide corresponding to C-KLDFLSALEEVIDN, from rat Ugt2b, at the internal region of the protein (aa423-436, NP_113721.3).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Chemiluminescence

(staining of Rat Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

Related Product Information for anti-UGT2B7 antibody

The UDP-glucuronosyltransferases (UGTs, EC 2.4.1.17) comprise a large family of proteins capable of detoxifying a wide variety of both endogenous and exogenous substrates. The primary function of this gene superfamily is to catalyze the glycosylation of substrates such as biogenic amines, steroids, bile acids, phenolic compounds and various other pharmacologically relevant compounds, including numerous carcinogens, toxic environmental pollutants and prescription drugs. This conjugation increases the solubility of these compounds, allowing them to be excreted more readily through hepatic or renal mechanisms

Product Categories/Family for anti-UGT2B7 antibody

Antibodies; Abs to Enzymes; Glycosyltransferase

NCBI and Uniprot Product Information

• NCBI GI #: 190194389
• NCBI GeneID: 7364
• NCBI Accession #: NP_001065.2
• NCBI GenBank Nucleotide #: NM_001074.2
• UniProt Accession #: P16662; Q6GTW0; B2R810
• Molecular Weight: 60,695 Da
• NCBI Official Full Name: UDP-glucuronosyltransferase 2B7
• NCBI Official Synonym Full Names: UDP glucuronosyltransferase 2 family, polypeptide B7
• NCBI Official Symbol: UGT2B7
• NCBI Official Synonym Symbols: UGT2B9; UDPGTH2; UDPGT2B7; UDPGT 2B9
• NCBI Protein Information: UDP-glucuronosyltransferase 2B7; UDPGTh-2; UDPGT 2B7; 3,4-catechol estrogen specific; UDP glucuronosyltransferase 2B7; UDP-glucuronosyltransferase 2B9; 3,4-catechol estrogen-specific UDPGT; UDP-glucuronyltransferase, family 2, beta-7
• UniProt Protein Name: UDP-glucuronosyltransferase 2B7
• Protein Family: UDP-glucuronosyltransferase
• UniProt Gene Name: UGT2B7
• UniProt Synonym Gene Names: UGTB2B9; UDPGT 2B7; UDPGT 2B9
• UniProt Entry Name: UD2B7_HUMAN

NCBI Description

The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. [provided by RefSeq, Sep 2011]

Uniprot Description

UGT2B7: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Belongs to the UDP-glycosyltransferase family.

Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Transferase; Xenobiotic Metabolism - metabolism by cytochrome P450; Membrane protein, integral; Lipid Metabolism - androgen and estrogen; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - ascorbate and aldarate; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; EC 2.4.1.17; Cofactor and Vitamin Metabolism - retinol; Carbohydrate Metabolism - pentose and glucuronate interconversions

Chromosomal Location of Human Ortholog: 4q13

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; membrane; integral to membrane

Molecular Function: retinoic acid binding; glucuronosyltransferase activity

Biological Process: flavonoid biosynthetic process; androgen metabolic process; lipid metabolic process; cellular response to hormone stimulus