Rabbit anti-Mouse, Rat UGGT Polyclonal Antibody | anti-Uggt1 antibody
UGGT (UDP-glucose glycoprotein Glucosyltransferase)
Gene Names
Uggt1; UGT1; Uggt; rUGT1; Ugcgl1
Reactivity
Mouse, Rat
Applications
Western Blot
Purity
SerumSerum
Synonyms
UGGT; Polyclonal Antibody; UGGT (UDP-glucose glycoprotein Glucosyltransferase); Anti -UGGT (UDP-glucose glycoprotein Glucosyltransferase); anti-Uggt1 antibody
Host
Rabbit
Reactivity
Mouse, Rat
Clonality
Polyclonal
Specificity
Recognizes a 170kD protein, corresponding to the apparent molecular mass of UGGT. Species Crossreactivity: mouse and rat cell lysates and tissue extracts.
Purity/Purification
Serum
Serum
Serum
Form/Format
Serum
Applicable Applications for anti-Uggt1 antibody
Western Blot (WB)
Application Notes
Dilution: Western Blot (Colorimetric): 1:100
Western Blot (ECL): 1:500
Western Blot (ECL): 1:500
Immunogen
A 15 residue synthetic MAP peptide based on rat UGGT sequence (EEKELGTLHEETQE).
Positive Control
Rat Brain Tissue Extract
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20 degree C or colder. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-Uggt1 antibody
UDP-glucose:glycoprotein glucosyltransferase (UGGT) is a 170kD lumenal endoplasmic reticulum (ER) resident protein that catalyzes monoglucosylation of high mannose oligosaccharides (1). UGGT catalyzes the transfer of glucose from UDP-glucose to Man7-9GlcNAc2-moiety of unfolded glycoproteins in a Ca2+ dependent reaction (2, 3). UGGT binds unfolded glycoprotein via two elements on its substrate: a N-acetylglucosamine unit on the oligosaccharide and hydrophobic amino acids that are exposed in the denatured conformation (4). It is postulated that UGGT serves as a sensor that is able to distinguish between folded and denatured protein in the ER.
Product Categories/Family for anti-Uggt1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
176,431 Da
NCBI Official Full Name
UDP-glucose:glycoprotein glucosyltransferase 1
NCBI Official Synonym Full Names
UDP-glucose glycoprotein glucosyltransferase 1
NCBI Official Symbol
Uggt1
NCBI Official Synonym Symbols
UGT1; Uggt; rUGT1; Ugcgl1
NCBI Protein Information
UDP-glucose:glycoprotein glucosyltransferase 1; RUGT; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1; UDP-glucose glycoprotein: glucosyltransferase UGGT
UniProt Protein Name
UDP-glucose:glycoprotein glucosyltransferase 1
Protein Family
UniProt Gene Name
Uggt1
UniProt Synonym Gene Names
Gt; Ugcgl1; Uggt; Ugt1; Ugtr; UGT1; rUGT1
UniProt Entry Name
UGGG1_RAT
NCBI Description
enzyme that catalyzes the addition of a glucose residue from UDP-glucose to an N -linked Man(9)GlcNAc(2)oligosaccharide [RGD, Feb 2006]
Uniprot Description
UGCGL1: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Belongs to the glycosyltransferase 8 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transferase; EC 2.4.1.-
Cellular Component: endoplasmic reticulum lumen; endoplasmic reticulum; ER-Golgi intermediate compartment
Molecular Function: protein binding; unfolded protein binding; UDP-glucose:glycoprotein glucosyltransferase activity
Biological Process: 'de novo' posttranslational protein folding; protein folding; protein amino acid glycosylation
Research Articles on Uggt1
Similar Products
Product Notes
The Uggt1 uggt1 (Catalog #AAA613825) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The UGGT (UDP-glucose glycoprotein Glucosyltransferase) reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's UGGT can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Dilution: Western Blot (Colorimetric): 1:100 Western Blot (ECL): 1:500. Researchers should empirically determine the suitability of the Uggt1 uggt1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "UGGT, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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