Rabbit anti-Human, Mouse ATAD3A Polyclonal Antibody | anti-ATAD3A antibody

ATAD3A (ATPase Family AAA Domain-containing Protein 3A, FLJ10709) (PE)

Cat. Num. AAA6370605

• Gene Names: ATAD3A; HAYOS; PHRINL
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: ATAD3A; Polyclonal Antibody; ATAD3A (ATPase Family AAA Domain-containing Protein 3A; FLJ10709) (PE); anti-ATAD3A antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human ATAD3A. Species Crossreactivity: mouse.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
• Sequence Length: 2516

• Applicable Applications for anti-ATAD3A antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human ATAD3A, aa1-586 (AAH33109.1).
• Immunogen Sequence: MSWLFGINKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASEDGVLTEAMMDTRVQDAVQQHQQKMCWLKAEGPGRGDEPSPS
• Conjugate: PE
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(ATAD3A rabbit polyclonal antibody. Western Blot analysis of ATAD3A expression in human placenta.)

Western Blot (WB)

(ATAD3A rabbit polyclonal antibody. Western Blot analysis of ATAD3A expression in mouse kidney.)

Western Blot (WB)

(ATAD3A rabbit polyclonal antibody. Western Blot analysis of ATAD3A expression in HeLa.)

Western Blot (WB)

(Western Blot analysis of ATAD3A expression in transfected 293T cell line by ATAD3A polyclonal antibody. Lane 1: ATAD3A transfected lysate (66.2kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-ATAD3A antibody

Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis.

Product Categories/Family for anti-ATAD3A antibody

Antibodies; Enzymes; ATPase

NCBI and Uniprot Product Information

• NCBI GI #: 21620023
• NCBI GeneID: 55210
• NCBI Official Full Name: Homo sapiens ATPase family, AAA domain containing 3A, mRNA
• NCBI Official Synonym Full Names: ATPase family AAA domain containing 3A
• NCBI Official Symbol: ATAD3A
• NCBI Official Synonym Symbols: HAYOS; PHRINL
• NCBI Protein Information: ATPase family AAA domain-containing protein 3A
• Protein Family: ATPase family AAA domain-containing protein

NCBI Description

This gene encodes a ubiquitously expressed mitochondrial membrane protein that contributes to mitochondrial dynamics, nucleoid organization, protein translation, cell growth, and cholesterol metabolism. This gene is a member of the ATPase family AAA-domain containing 3 gene family which, in humans, includes two other paralogs. Naturally occurring mutations in this gene are associated with distinct neurological syndromes including Harel-Yoon syndrome. High-level expression of this gene is associated with poor survival in breast cancer patients. A homozygous knockout of the orthologous gene in mice results in embryonic lethality at day 7.5 due to growth retardation and defective development of the trophoblast lineage. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]