Rabbit anti-Human TXNDC17 Polyclonal Antibody | anti-TXNDC17 antibody
Anti-TXNDC17 Antibody, Rabbit Polyclonal
Gene Names
TXNDC17; TRP14; TXNL5
Reactivity
Human
Applications
ELISA
Purity
Protein A & Antigen Affinity
Synonyms
TXNDC17; Polyclonal Antibody; Anti-TXNDC17 Antibody; Rabbit Polyclonal; TXNDC17 Antibody; Rabbit PAb; Antigen Affinity Purified; thioredoxin domain containing 17; Anti-TRP14 Antibody; Anti-TXNL5 Antibody; anti-TXNDC17 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human TXNDC17
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-TXNDC17 antibody
ELISA (EIA)
Application Notes
ELISA: 1:5000-1:10,000
Immunogen
Recombinant Human TXNDC17 protein
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with purified, recombinant Human TXNDC17 (rh TXNDC17). TXNDC17 specific IgG was purified by Human TXNDC17 affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-TXNDC17 antibody
Thioredoxin-related protein of 14 kDa (TRP14, also called TXNDC17 for thioredoxin domain containing 17, or TXNL5 for thioredoxin-like 5) is an evolutionarily well-conserved member of the thioredoxin (Trx)-fold protein family that lacks activity with classical Trx1 substrates. TXNDC17 is a novel 14-kDa disulfide reductase of the TXN (thioredoxin) family. TXNDC17 is involved in the TNF (tumor necrosis factor) signaling pathway. Moreover, TXNDC17 plays an important role in Taxol resistance via enhancing autophagy in human colorectal cancer cells. And TXNDC17 may become a potential target of colorectal cancer therapeutics.
References
Holmgren A. (1985) Thioredoxin. Annu Rev Biochem. 54: 237-71.Holmgren A. (1995) Thioredoxin structure and mechanism: conformational changes on oxidation of the active-site sulfhydryls to a disulfide. Structure. 3 (3): 239-43.Martin JL. (1995) Thioredoxin--a fold for all reasons. Structure. 3 (3): 245-50.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
13,941 Da
NCBI Official Full Name
thioredoxin domain-containing protein 17
NCBI Official Synonym Full Names
thioredoxin domain containing 17
NCBI Official Symbol
TXNDC17
NCBI Official Synonym Symbols
TRP14; TXNL5
NCBI Protein Information
thioredoxin domain-containing protein 17; 14 kDa thioredoxin-related protein; protein 42-9-9; thioredoxin (Trx)-related protein, 14 kDa; thioredoxin-like 5; thioredoxin-like protein 5
UniProt Protein Name
Thioredoxin domain-containing protein 17
UniProt Gene Name
TXNDC17
UniProt Synonym Gene Names
TXNL5; TRP14
UniProt Entry Name
TXD17_HUMAN
Uniprot Description
TXNL5: Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide. Belongs to the thioredoxin family.
Protein type: Oxidoreductase
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: cytosol
Molecular Function: protein-disulfide reductase activity; protein binding; peroxidase activity; electron carrier activity
Biological Process: tumor necrosis factor-mediated signaling pathway
Research Articles on TXNDC17
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Product Notes
The TXNDC17 txndc17 (Catalog #AAA8105229) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TXNDC17 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TXNDC17 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 1:5000-1:10,000. Researchers should empirically determine the suitability of the TXNDC17 txndc17 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TXNDC17, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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